Evidence map›Paper›PMID 40867619›Full record

ArticleBiomolecules2025

Novel Neuroactive Steroid Analogs and Voltage-Dependent Blockers of Ca

Benjamin Volvovitz, Rakib Miah, Kibeom Park, Jae Hun Kim, Raul Vargas, Yuanjiang Xu, Mingxing Qian, Douglas F Covey, Slobodan M Todorovic, Vesna Jevtovic-Todorovic

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin VolvovitzDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0009-0002-4266-9776
Rakib MiahDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-8637-123X
Kibeom ParkDepartment of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, School of Medicine, Keimyung University, 1035, Dalgubeol-daero, Dalseo-gu, Daegu 42601, Republic of Korea.ORCID 0000-0002-1432-8301
Jae Hun KimDepartment of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1, Neungdong-ro (Hwayang-dong), Gwangjin-gu, Seoul 05030, Republic of Korea.
Raul VargasDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0009-0002-1862-1510
Yuanjiang XuDepartment of Developmental Biology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA.ORCID 0009-0003-1108-3286
Mingxing QianDepartment of Developmental Biology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA.ORCID 0000-0002-2106-2855
Douglas F CoveyDepartment of Developmental Biology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA.
Slobodan M TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-2613-0391
Vesna Jevtovic-TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2M
Voltage-gated calcium channels as target for anestheticsR35GM141802 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Slobodan M. Todorovic · 2021 to 2026
$3.1M
Novel neurosteroid anesthetics and developmental synaptogenesisR01HD097990 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2019 to 2023
$2.9M
Novel neurosteroid anesthetics and perioperative analgesiaR01GM123746 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2017 to 2025
$2.2M
FVMPE-RS Riser System for in vivo and in vitro imaging on anesthesia-induced developmental neurotoxicityR01GM118197 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2016 to 2019
$1.7M
Anesthesiology Mentored Research TrainingT32GM135169 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Susan L Ingram, Vesna Jevtovic-Todorovic · 2021 to 2026
$1.0M
BLRD VA I01 BX004763NICHD NIH HHS R01 HD097990NIGMS NIH HHS R01 GM118197NIGMS NIH HHS R01 GM123746NIGMS NIH HHS R35 GM141802NIGMS NIH HHS T32 GM135169NIH/GMS R35GM141802NIH HHS MH122379NIH HHS R01GM123746NIMH NIH HHS P50 MH122379VA 1I01BX004763
6 · The paper itself

Abstract

Although opioids are effective in treating pain, they cause serious side effects. The use of regional anesthesia, although effective in the perioperative period, may not be suitable if mobility and lack of numbness is desired. Hence, there is a clear need for novel pain therapies. Low-voltage activated (T-type) calcium channels (Ca

Indexed as

AnalgesicsCalcium Channel BlockersCalcium Channels, T-TypeHypnotics and SedativesNeurosteroidsSteroidsAnimalsFemaleHumansMiceAnalgesicsCacna1h protein, mouseCalcium Channel BlockersCalcium Channels, T-TypeHypnotics and SedativesNeurosteroidsSteroidscalcium channelsGABAmechanical sensitivitypainsedation/hypnosis

Identifiers

PMID40867619
PMCPMC12385050

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.