Evidence map›Paper›PMID 40867580›Full record

ArticleBiomolecules2025

Gosha-Jinki-Gan Reduces Inflammation in Chronic Ischemic Stroke Mouse Models by Suppressing the Infiltration of Macrophages.

Mingli Xu, Kaori Suyama, Kenta Nagahori, Daisuke Kiyoshima, Satomi Miyakawa, Hiroshi Deguchi, Yasuhiro Katahira, Izuru Mizoguchi, Hayato Terayama, Shogo Hayashi and 2 more

Abstract read
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In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mingli XuDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.
Kaori SuyamaDepartment of Anatomy, Tokai University School of Medicine, Isehara 259-1193, Japan.
Kenta NagahoriDepartment of Anatomy, Tokai University School of Medicine, Isehara 259-1193, Japan.
Daisuke KiyoshimaDepartment of Anatomy, Tokai University School of Medicine, Isehara 259-1193, Japan.ORCID 0000-0002-7746-2858
Satomi MiyakawaDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.
Hiroshi DeguchiDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.
Yasuhiro KatahiraDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.ORCID 0000-0003-3493-1172
Izuru MizoguchiDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.
Hayato TerayamaDepartment of Anatomy, Tokai University School of Medicine, Isehara 259-1193, Japan.ORCID 0000-0002-7053-8418
Shogo HayashiDepartment of Anatomy, Tokai University School of Medicine, Isehara 259-1193, Japan.ORCID 0000-0003-0302-7658
Takayuki YoshimotoDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.ORCID 0000-0002-2847-0341
Ning QuDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan.ORCID 0000-0001-5110-6719

Funding

Grant-in-Aid for General Science Research from the Ministry of Education, Science, Sports, and Culture in Japan. C: 21K11227
6 · The paper itself

Abstract

Ischemic stroke is a primary cause of cerebrovascular diseases and continues to be one of the leading causes of death and disability among patients worldwide. Pathological processes caused by vascular damage due to stroke occur in a time-dependent manner and are classified into three categories: acute, subacute, and chronic. Current treatments for ischemic stroke are limited to effectiveness in the early stages. In this study, we investigated the therapeutic effect of an oriental medicine, Gosha-jinki-gan (TJ107), on improving chronic ischemic stroke using the mouse model with middle cerebral artery occlusion (MCAO). The changes in the intracerebral inflammatory response (macrophages (

Indexed as

Drugs, Chinese HerbalInflammationIschemic StrokeMacrophagesAnimalsCytokinesDisease Models, AnimalInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLCytokinesDrugs, Chinese Herbalchronic ischemic strokeglial fibrillary acidic protein (GFAP)Gosha-jinki-gan (TJ107)inflammationmacrophagemiddle cerebral artery occlusion (MCAO)

Identifiers

PMID40867580
PMCPMC12384214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.