Evidence map›Paper›PMID 40867530›Full record

ArticleBiomolecules2025

Increased Concentration of Anti-Egg Albumin Antibodies in Cerebrospinal Fluid and Serum of Patients with Alzheimer's Disease-Discussion on Human Serpins' Similarity and Probable Involvement in the Disease Mechanism.

Dionysia Amanatidou, Magdalini Tsolaki, Vasileios Fouskas, Ioannis Gavriilidis, Maria Myriouni, Anna Anastasiou, Efthimia Papageorgiou, Diona Porfyriadou, Zoi Parcharidi, Eleftheria Papasavva and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dionysia AmanatidouSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.ORCID 0000-0002-5849-4192
Magdalini TsolakiLaboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTh), Balkan Center, Aristotle University of Thessaloniki, Building A, 57001 Thessaloniki, Greece.ORCID 0000-0002-2072-8010
Vasileios FouskasSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.
Ioannis GavriilidisSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.
Maria MyriouniSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.
Anna AnastasiouLaboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTh), Balkan Center, Aristotle University of Thessaloniki, Building A, 57001 Thessaloniki, Greece.
Efthimia PapageorgiouLaboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTh), Balkan Center, Aristotle University of Thessaloniki, Building A, 57001 Thessaloniki, Greece.
Diona PorfyriadouSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.
Zoi ParcharidiSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.ORCID 0009-0009-0150-8993
Eleftheria PapasavvaSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.
Maria FiliSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.
Phaedra EleftheriouSchool of Health, Department of Biomedical Sciences, International Hellenic University, Sindos, 57400 Thessaloniki, Greece.ORCID 0000-0001-8376-752X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's Disease (AD) is a multifactorial process. Amyloid plaque formation constitutes the main characteristic of the disease. Despite the identification of numerous factors associated with AD, the mechanism remains unclear in several aspects. Disturbances in intestinal and blood-brain barrier (BBB) penetration, observed in AD, may facilitate immunologic response to food-derived antigens. In the present study, antibodies against egg albumin, bovine-casein, and N-Glycolyl-Neuraminic acid (Neu5Gc) were measured in the cerebrospinal fluid (CSF) and serum of the patients using an enzyme-linked immunosorbent assay (ELISA). Zero anti-Neu5Gc and low concentrations of anti-casein antibodies were detected. Increased anti-native egg albumin antibodies were present in the serum of patients of all stages with 65% positivity (

Indexed as

AlbuminsAlzheimer DiseaseAntibodiesAgedAged, 80 and overAnimalsCattleEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedNeuraminic AcidsAlbuminsAntibodiesNeuraminic AcidsN-glycolylneuraminic acidAlzheimer’s DiseaseantibodiescaseinCSFegg albumingendernative/denaturedsequence/structural similarityserpinsserum

Identifiers

PMID40867530
PMCPMC12383860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.