Evidence map›Paper›PMID 40867523›Full record

ArticleBiomolecules2025

Artesunate Ameliorates SLE Atherosclerosis Through PPARγ-Driven Cholesterol Efflux Restoration and Disruption of Lipid Raft-Organized TLR9/MyD88 Signaling Pathway.

Miao Zhang, Xinyu Pan, Yuanfang He, Kairong Sun, Zhiyu Wang, Weiyu Tian, Haonan Qiu, Yiqi Wang, Chengping Wen, Juan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miao ZhangInstitute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Xinyu PanInstitute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Yuanfang HeInstitute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Kairong SunInstitute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Zhiyu WangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Weiyu TianNingbo Taikang Hospital, Ningbo 315000, China.
Haonan QiuThe Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310029, China.
Yiqi WangSchool of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Chengping WenInstitute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Juan ChenInstitute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China.ORCID 0009-0005-5823-2239

Funding

he Zhejiang Chinese Medicine University Scientific Research Fund Project 2021YKJ20Joint Fund of the National Natural Science Foundation of China No. U21A20402National Natural Science Foundation of China 81603363National Natural Science Foundation of China 81803806Natural Science Foundation of Zhejiang Province LY23H290002
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is characterized by autoimmune dysregulation, elevated autoantibody production, and persistent inflammation, predisposing patients to atherosclerosis (AS). Atherogenesis is dependent on lipid homeostasis and inflammatory processes, with the formation of lipid-laden, macrophage-derived foam cells (MDFC) essential for atherosclerotic lesion progression. Elevated cholesterol levels within lipid rafts trigger heightened pro-inflammatory responses in macrophages via Toll-like receptor 9 (TLR9). Artesunate (ART), an artemisinin derivative sourced from

Indexed as

ArtesunateAtherosclerosisCholesterolLupus Erythematosus, SystemicMembrane MicrodomainsMyeloid Differentiation Factor 88PPAR gammaToll-Like Receptor 9AnimalsATP Binding Cassette Transporter 1MacrophagesMiceMice, Inbred C57BLSignal TransductionArtesunateATP Binding Cassette Transporter 1CholesterolMyd88 protein, mouseMyeloid Differentiation Factor 88PPAR gammaTlr9 protein, mouseToll-Like Receptor 9cholesterol effluxcholesterol homeostasisinflammationlipid raftSLE atherosclerosisTLR9/MyD88

Identifiers

PMID40867523
PMCPMC12383290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.