Evidence map›Paper›PMID 40867516›Full record

ArticleBiomolecules2025

Optimization and Characterization of Bioactive Metabolites from Cave-Derived

Muhammad Rafiq, Umaira Bugti, Muhammad Hayat, Wasim Sajjad, Imran Ali Sani, Nazeer Ahmed, Noor Hassan, Yanyan Wang, Yingqian Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad RafiqGuizhou Key Laboratory of Microbiome and Infectious Disease Prevention and Control, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou, School of basic Medical Sciences, Joint Laboratory of Shanghai Dongli One Health Research Institute Co., Ltd., Guizhou Medical University One Health Research Institute, Gui'an 561113, China.ORCID 0000-0001-6098-4142
Umaira BugtiDepartment of Microbiology, Faculty of Life Sciences and Informatics, Balochistan University of IT, Engineering and Management Sciences, Quetta 87300, Pakistan.
Muhammad HayatState Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
Wasim SajjadKey Laboratory of Cryospheric Science and Frozen Soil Engineering, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.ORCID 0000-0002-1622-0484
Imran Ali SaniDepartment of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of IT, Engineering and Management Sciences, Quetta 75000, Pakistan.
Nazeer AhmedDepartment of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of IT, Engineering and Management Sciences, Quetta 75000, Pakistan.
Noor HassanNational Institute for Biotechnology and Genetic Engineering-College (NIBGE-C), Pakistan Institute of Engineering and Applied Sciences (PIEAS), Faisalabad 39000, Pakistan.ORCID 0000-0002-6619-6806
Yanyan WangGuizhou Key Laboratory of Microbiome and Infectious Disease Prevention and Control, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou, School of basic Medical Sciences, Joint Laboratory of Shanghai Dongli One Health Research Institute Co., Ltd., Guizhou Medical University One Health Research Institute, Gui'an 561113, China.
Yingqian KangGuizhou Key Laboratory of Microbiome and Infectious Disease Prevention and Control, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou, School of basic Medical Sciences, Joint Laboratory of Shanghai Dongli One Health Research Institute Co., Ltd., Guizhou Medical University One Health Research Institute, Gui'an 561113, China.

Funding

National "111" Project (D20009); International Science and Technology Cooperation Base of Guizhou Province (QKBPT GHJD〔2025〕006)； National Natural Science Foundation of China （no.32460051/32060034) D20009; 32460051/32060034
6 · The paper itself

Abstract

Extremophilic microorganisms offer an untapped potential for producing unique bioactive metabolites with therapeutic applications. In the current study, bacterial isolates were obtained from samples collected from Chamalang cave located in Kohlu District, Balochistan, Pakistan. The cave-derived isolate C1 (

Indexed as

Anti-Bacterial AgentsCavesRhodococcusAntioxidantsCarbonDrug Resistance, Multiple, BacterialEscherichia coliMicrobial Sensitivity TestsMicrococcus luteusNitrogenStaphylococcus aureusAnti-Bacterial AgentsAntioxidantsCarbonNitrogenantibioticscaves microbesextremotolerant bacterianovel bioactive metabolites

Identifiers

PMID40867516
PMCPMC12383431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.