Evidence map›Paper›PMID 40867346›Full record

ArticleCancers2025

Comprehensive Longitudinal Linear Mixed Modeling of CTCs Illuminates the Role of Trop2, EpCAM, and CD45 in CTC Clustering and Metastasis.

Seth D Merkley, Huining Kang, Ursa Brown-Glaberman, Dario Marchetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seth D MerkleyDivision of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Huining KangDivision of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-4415-3573
Ursa Brown-GlabermanChristus St. Vincent Regional Cancer Center, Santa Fe, NM 85705, USA.
Dario MarchettiDivision of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-5951-2823

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Functional characterization of brain-colonizing breast cancer CTC subsetsR01CA193213 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MARCHETTI, DARIO · 2015 to 2021
$1.8M
NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA193213NIH/NCI 1R01 CA193213
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

breast cancer metastasisCD45CTCCTC clustersCytokeratinEpCAMliquid biopsyTrop2

Identifiers

PMID40867346
PMCPMC12384426

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.