Evidence map›Paper›PMID 40867343›Full record

ArticleCancers2025

Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in

Tasmia Tahsin, Darius K McPhail, Jesse D Champion, Mohammad A M Alzahrani, Madeleine L Hilditch, Alexandre Faris-Orr, Brian L Calver, James G Cronin, Juan C Mareque-Rivas, Darren W Sexton and 4 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tasmia TahsinInstitute of Life Science, Swansea University Medical School, Faculty of Medicine, Health & Life Science, Swansea University, Swansea SA2 8PP, UK.
Darius K McPhailDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID 0009-0006-4490-2972
Jesse D ChampionDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Mohammad A M AlzahraniDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Madeleine L HilditchDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Alexandre Faris-OrrDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Brian L CalverDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
James G CroninInstitute of Life Science, Swansea University Medical School, Faculty of Medicine, Health & Life Science, Swansea University, Swansea SA2 8PP, UK.ORCID 0000-0002-0590-9462
Juan C Mareque-RivasDepartment of Chemistry, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
Darren W SextonSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.ORCID 0000-0003-3344-3150
Stephen Fôn HughesMaelor Academic Unit of Medical & Surgical Sciences (MAUMSS), Betsi Cadwaladr University Health Board (BCUHB), Faculty of Social & Life Sciences, Wrexham University, Gwenfro Buildings, Technology Park, Wrexham LL13 7YP, UK.ORCID 0000-0001-6558-9037
Robert Steven ConlanInstitute of Life Science, Swansea University Medical School, Faculty of Medicine, Health & Life Science, Swansea University, Swansea SA2 8PP, UK.ORCID 0000-0002-2562-3461
David Mark DaviesDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Andrew R TeeDivision of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID 0000-0002-5577-4631

Funding

Therapeutic potential of targeting DNA repair deficiency in TSCR21CA263133 · NCI · MICHIGAN STATE UNIVERSITY · PI MACKEIGAN, JEFFREY PAUL · 2021 to 2022
$399k
NCI NIH HHS R21 CA263133Welsh Government's European Social Fund (ESF) convergence programme for West Wales and the Valleys KESS II and BCUHB; Cancer Research Wales PhD studentship;Cancer Research Wales Fellowship,Tuberous Sclerosis Association; King Fahd Security College/Ministr grant number 2504; grant number 2527, grant number 2018-S04; grant number 1050795978; grant number R21CA263133
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cancer resistanceferroptosisFSP1mTORNRF2RSL3tuberous sclerosis complex

Identifiers

PMID40867343
PMCPMC12384948

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.