ArticleCancers2025
The Cervical Lymph Node Positive Metastatic Probability Is a Significant Predictor of Survival for Oral Squamous Cell Carcinoma-A Nationwide Study.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial Intelligence-Driven MRI for Cervical Nodal Metastasis Detection in Oral Squamous Cell Carcinoma: A Hierarchical Meta-Analysis of Diagnostic Accuracy.Head & neck · 2026Pooled it
- Article
- Level II (IIA/IIB) Lymph Node Evaluation in Head and Neck Cancer: A Retrospective Cohort Study from a Non-Endemic Region.Journal of clinical medicine · 2026Article
- Prognostic Factors of Locally Advanced Cutaneous Squamous Cell Carcinoma in Head and Neck Region in Transplanted Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Incidence of pathologically positive lymph node in clinico-radiologic T4b oral squamous cell carcinoma: a meta-analysis.Ecancermedicalscience · 2026Review
- Pattern of Mandibular Bone Invasion as a Prognostic Factor.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
BACKGROUND/
objectivesThis study aimed to evaluate the prognostic significance of lymph node density (LND) and the log odds of positive lymph nodes (LODDS) in patients with oral squamous cell carcinoma (OSCC) using a nationwide database.
methodsA retrospective cohort study was conducted using the Taiwan Cancer Registry to identify patients diagnosed with OSCC who underwent surgery for both the primary tumor and neck dissection. Clinicopathological variables were collected, and survival outcomes were analyzed using Cox proportional hazards models. LND was categorized as negative, <0.05, and ≥0.05; LODDS was grouped into four categories: <-4, -4 to -3.5, -3.5 to -2.5, and ≥-2.5.
resultsA total of 1643 female and 15,475 male patients were included, with a mean age of 57.4 years (range, 20-98 years). In multivariable Cox regression analyses, LND and LODDS were identified as independent prognostic factors for overall survival. Compared with patients with negative LND, the hazard ratios for LND < 0.05 and LND ≥0.05 were 2.12 (95% CI, 1.90-2.36) and 3.35 (95% CI, 3.05-3.67), respectively (
conclusionsLND and LODDS are significant prognostic indicators in OSCC. Incorporating these lymph node-based metrics into prognostic models may enhance risk stratification and inform clinical decision-making.
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Registered trials
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