Evidence map›Paper›PMID 40867295›Full record

ArticleCancers2025

Global Hypomethylation as Minimal Residual Disease (MRD) Biomarker in Esophageal and Esophagogastric Junction Adenocarcinoma.

Elisa Boldrin, Maria Assunta Piano, Alice Volpato, Rita Alfieri, Monica Franco, Tiziana Morbin, Annalisa Masier, Stefano Realdon, Genny Mattara, Giovanna Magni and 4 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elisa BoldrinImmunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-7898-5845
Maria Assunta PianoImmunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-7701-887X
Alice VolpatoAnatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0009-0008-2478-6390
Rita AlfieriGeneral Gastric and Esophagus Surgery Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy.ORCID 0000-0002-4993-2197
Monica FrancoGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0009-0003-7329-3713
Tiziana MorbinGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-1041-5192
Annalisa MasierGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Stefano RealdonOncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-6843-7637
Genny MattaraSurgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-8880-0840
Giovanna MagniClinical Research Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0003-1839-2586
Antonio RosatoImmunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Pierluigi PilatiSurgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Alberto FantinGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-7206-9117
Matteo CurtarelloImmunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0003-3133-4807

Funding

Istituto Oncologico Veneto BIOV19BOLDRIMinistero della Salute RICERCA CORRENTE 2024
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Barrett’s esophagus (BE)esophageal adenocarcinoma (EADC)esophagogastric junction adenocarcinoma (EGJA)global hypomethylationliquid biopsyMethylation-Sensitive Restriction Enzyme droplet digital PCR (MSRE-ddPCR)minimal residual disease (MRD)

Identifiers

PMID40867295
PMCPMC12384112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.