Evidence map›Paper›PMID 40867266›Full record

ReviewCancers2025

PET/CT and Paraneoplastic Syndromes: A Comprehensive Review.

Motaz Daraghma, Yashant Aswani, Sanchay Jain, Riccardo Laudicella, Ali Gholamrezanezhad, Yusuf Menda, Ahmad Shariftabrizi

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Metabolic bone disorders: what the internist must not overlook].Innere Medizin (Heidelberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Motaz DaraghmaSaint Luke's Hospital of Kansas City, University of Missouri-Kansas City, Kansas City, MO 64110, USA.
Yashant AswaniDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Sanchay JainDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Riccardo LaudicellaNuclear Medicine Unit, Department of Biomedical, Dental Sciences and Morpho-Functional Imaging, Messina University, 98122 Messina, Italy.ORCID 0000-0002-2842-0301
Ali GholamrezanezhadDepartment of Radiology, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA 90089, USA.
Yusuf MendaDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Ahmad ShariftabriziDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.ORCID 0000-0003-2397-6914

Funding

Project 3: GLP1R and GIPR Agonists in GEP NETs ProjectP50CA302572 · NCI · UNIVERSITY OF IOWA · PI JAMES R HOWE · 2025 to 2026
$6.5M
NCI NIH HHS P50 CA302572
6 · The paper itself

Abstract

Paraneoplastic syndromes (PNSs) are pathologic conditions produced by neoplasms not attributable to tumor invasion or metastasis. The clinical manifestations of PNSs can precede the diagnosis; these symptoms may serve as early indicators of underlying malignancy. Standard imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), have limited sensitivity in detecting small or early-stage PNS-associated tumors. FDG PET/CT identifies hypermetabolic lesions suggestive of malignancy and, therefore, facilitates early diagnosis, refined treatment planning, and potentially prolonged patient survival. This review evaluates the diagnostic accuracy, clinical utility, and emerging role of FDG PET/CT in detecting occult malignancies. Syndrome-targeted applications discussed include limbic encephalitis, cerebellar degeneration, Lambert-Eaton myasthenic syndrome, Cushing's syndrome, hypercalcemia of malignancy, dermatomyositis, and tumor-induced osteomalacia. In addition, the limitations of FDG PET/CT, including false-positive or false-negative findings, are reviewed, while newer PET tracers, like

Indexed as

DOTATATEFDGmetabolic imagingoccult malignancy detectionparaneoplastic symptomspositron emission tomography

Identifiers

PMID40867266
PMCPMC12384497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.