Evidence map›Paper›PMID 40867234›Full record

ReviewCancers2025

The Effects of Radiation Therapy on the Ocular Apparatus: Implications for Management.

Frank J Arturi, Danielle Arons, Nicholas J Murphy, Catherine Yu, Drishti Panse, Daniel R Cherry, Kristin Hsieh, Julie R Bloom, Anthony D Nehlsen, Lucas Resende Salgado and 1 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Frank J ArturiCollege of Medicine, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.ORCID 0009-0008-2088-6634
Danielle AronsDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nicholas J MurphyDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-9265-994X
Catherine YuDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4967-6100
Drishti PanseDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Daniel R CherryDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kristin HsiehDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4100-473X
Julie R BloomDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-3819-7852
Anthony D NehlsenDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-3210-1415
Lucas Resende SalgadoDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kunal K SindhuDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-9376-8307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is utilized in the treatment of various cancers of the central nervous system and head and neck. Given the high concentration of organs-at-risk in this region, care must be exercised to minimize the dose delivered to these structures. Studies have shown that excessive radiation exposure can adversely impact the eyes, potentially resulting in the loss of their function. For instance, radiation doses greater than 50 Gy have been shown to increase the incidence of retinopathy, and radiation doses as low as 0.5 Gy have been shown to induce cataract formation. In this review, we discuss the ocular complications of radiotherapy used in the treatment of cancers of the central nervous system and head and neck. We then transition to potential strategies to spare the eyes during radiotherapy in an effort to reduce the rates and severity of ocular complications and preserve vision.

Indexed as

central nervous systemhead and neck cancerocular complicationsorgan-at-riskradiation oncologyradiotherapyuveal melanoma

Identifiers

PMID40867234
PMCPMC12384690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.