ArticleBrain sciences2025
Emotional Brain Development: Neurobiological Indicators from Fetus Through Toddlerhood.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications.World journal of clinical pediatrics · 2026Review
- Protocol and Preliminary Findings from the BrainPALS Study in Very Preterm Children: A Randomized Controlled Trial of a Digital Parenting Program.Children (Basel, Switzerland) · 2026Article
- Relationship of Emotional Functioning in 9-12-Year-Old Schoolchildren with Key Lifestyles: Sleep Quality and Daily Physical Activity.Children (Basel, Switzerland) · 2026Article
- ASQ-3 developmental outcomes at six months in a Bulgarian infant cohort: a cross-cultural comparison with U.S. norms.Frontiers in pediatrics · 2026Article
- Breaking the Cycle: Impact of Physical Activity on Sleep Disorders in Autism-A Five-Year Longitudinal Analysis.Children (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maturation of brain regions involved in emotion regulation-particularly the amygdala and prefrontal cortex-from fetal life to age two is a dynamic process shaped by genetic and environmental factors. Early experiences, especially responsive caregiving, promote the growth of neural circuits supporting emotional expression and regulation. In contrast, early adversity such as neglect or chronic stress may disrupt these circuits and increase vulnerability to emotional difficulties. Elevated levels of placental CRH are linked to alterations in fetal brain development related to emotion. Neurodevelopmental processes like synaptic pruning and myelination, active during the first years, further shape emotional circuitry. These findings underscore the importance of early caregiving and timely interventions in fostering healthy emotional development. The present article proposes an integrative conceptual framework for early emotional and cognitive development, combining neurobiological models with contemporary theories in developmental psychology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.