ArticleBrain sciences2025
Acute Ischemic Stroke Treatment in Germany (2015-2023): Nationwide Trends in Thrombolysis and Thrombectomy by Age and Sex.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Trends of Major Cerebrovascular Procedures After Mechanical Thrombectomy Implementation: A Nationwide Observational Study in Germany (2015-2023).Brain sciences · 2026Article
- Spatiotemporal analysis of hospitalizations, mortality and access to intravenous thrombolysis for ischemic stroke in Southern Brazil.BMC public health · 2026Article
- The multi-target protective effects of quercetin in cerebrovascular diseases: a dietary strategy for endothelial repair and neuroprotection.Frontiers in nutrition · 2026Review
- From Electron Imbalance to Network Collapse: Decoding the Redox Code of Ischemic Stroke for Biomarker-Guided Precision Neuroprotection.International journal of molecular sciences · 2025Review
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Authors and funding
4 authors.
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Abstract
backgroundThe implementation of intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) in acute ischemic stroke (AIS) has proven effective, offering significant benefits for patient outcomes. We therefore investigated trends in the implementation of IVT and MT in Germany between 2015 and 2023.
methodsWe conducted a retrospective analysis using German Diagnosis-Related Group (DRG) statistics from 2015 to 2023. Treatment numbers were analyzed annually based on OPS codes. We examined the age and sex distribution of patients undergoing these treatments. Additionally, we analyzed all hospital cases coded with ICD-10 for acute ischemic stroke (AIS).
resultsBetween 2015 and 2023, the number of AIS cases in Germany slightly declined from 250,802 to 248,107 (-1.1%), with the largest annual decrease (-4.3%) occurring during the COVID-19 pandemic (2019-2020). Despite this, the use of IVT increased from 40,766 cases (16.25%) in 2015 to 48,378 (19.50%) in 2023. MT usage rose even more sharply, from 7840 cases (3.13%) to 22,445 (9.05%). Among MT recipients, the proportion of patients aged ≥80 years rose significantly, from 27.2% to 42.1%. In this age group, women consistently comprised the majority of MT patients-65.4% in 2015 and 65.5% in 2023.
conclusionsDespite a stable stroke incidence, the use of IVT-and particularly MT-continued to increase in Germany from 2015 to 2023, even during the COVID-19 pandemic. MT usage nearly tripled, especially among patients aged ≥80 years. These trends highlight a resilient stroke care system and underscore the need for future planning to meet the rising demand for endovascular treatment in an aging population.
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