Evidence map›Paper›PMID 40867128›Full record

ArticleBrain sciences2025

The Role of Cognitive Reserve in Coping with Subjective Cognitive Complaints: An Exploratory Study of People with Parkinson's Disease (PwPD).

Chiara Siri, Anna Carollo, Roberta Biundo, Maura Crepaldi, Luca Weis, Ioannis Ugo Isaias, Angelo Antonini, Maria Luisa Rusconi, Margherita Canesi

Abstract read
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Subjective cognitive complaints in cognitively unimpaired Parkinson's disease: Associations with affective burden, motor severity, and awareness-related processes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara SiriU.O.C. Neurorehabilitation Unit, Parkinson's Disease and Movement Disorders Center, Moriggia Pelascini Hospital, Via Moriggia Pelascini, 3, 22015 Gravedona ed Uniti, Italy.ORCID 0000-0002-9199-4084
Anna CarolloU.O.C. Neurorehabilitation Unit, Parkinson's Disease and Movement Disorders Center, Moriggia Pelascini Hospital, Via Moriggia Pelascini, 3, 22015 Gravedona ed Uniti, Italy.
Roberta BiundoDepartment of General Psychology, University of Padua, Via Venezia, 8, 35131 Padua, Italy.
Maura CrepaldiDepartment of Human and Social Sciences, University of Bergamo, Piazzale S. Agostino, 2, 24129 Bergamo, Italy.ORCID 0000-0001-7671-6679
Luca WeisIRCCS, San Camillo Hospital, Via Alberoni, 70, 30126 Venice, Italy.ORCID 0000-0002-2286-0795
Ioannis Ugo IsaiasParkinson Institute, ASST "G.Pini-CTO", Via Emilio Bignami 1, 20126 Milan, Italy.
Angelo AntoniniIRCCS, San Camillo Hospital, Via Alberoni, 70, 30126 Venice, Italy.ORCID 0000-0003-1040-2807
Maria Luisa RusconiDepartment of Human and Social Sciences, University of Bergamo, Piazzale S. Agostino, 2, 24129 Bergamo, Italy.ORCID 0000-0001-9958-1498
Margherita CanesiU.O.C. Neurorehabilitation Unit, Parkinson's Disease and Movement Disorders Center, Moriggia Pelascini Hospital, Via Moriggia Pelascini, 3, 22015 Gravedona ed Uniti, Italy.ORCID 0000-0002-2642-6195

Funding

This study was supported by the Ministry of Health under Grant Number GR-2016-02361986
6 · The paper itself

Abstract

BACKGROUND/

objectivesDepression, anxiety and apathy are often associated with subjective cognitive complaints (SCCs) in people with Parkinson's disease (PwPD) without cognitive impairment. Cognitive reserve (CR) enhances emotional resilience, allowing people to better cope with stress and emotional challenges, factors affecting quality of life. We aimed to explore the relationship between CR and mood/anxiety in cognitively intact PwPD with and without SCCs.

methodsIn this cross-sectional study we enrolled 133 PwPD and normal cognitive function (age 59.8 ± 6.7 years; disease duration 9.0 ± 5.5 years; male/female 84/49). We assessed cognitive reserve (CR scale), subjective cognitive complaints (with PD-CFRS), QoL (PDQ8), mood, anxiety and apathy (BDI-II; STAI, PAS, Apathy scales). We used a

resultsThe group with SCCs had significantly (

conclusionsPwPD and SCCs are more depressed and anxious compared to people without SCCs. Furthermore, we found a relationship between depressive symptoms, anxiety and CR: PwPD with SCCs may rely on cognitive reserve to better cope with the feeling of anxiety and depression, especially in male gender.

Indexed as

cognitioncognitive reserveneurodegenerative disorderParkinson diseasequality of lifesubjective cognitive complaints

Identifiers

PMID40867128
PMCPMC12384381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.