Evidence map›Paper›PMID 40867092›Full record

ArticleAddiction (Abingdon, England)2025

Exploratory analysis of United States-based cannabis product health benefit claims on online marketplaces.

Matthew C Nali, Meng Zhen Larsen, Zhuoran Li, Jiawei Li, Douglas R Roehler, Vanessa Mallory, Tim K Mackey

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew C NaliSan Diego Supercomputer Center, University of California, San Diego, CA, USA.
Meng Zhen LarsenSan Diego Supercomputer Center, University of California, San Diego, CA, USA.
Zhuoran LiSan Diego Supercomputer Center, University of California, San Diego, CA, USA.
Jiawei LiS-3 Research, San Diego, CA, USA.
Douglas R RoehlerDivision of Overdose Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-3646-7174
Vanessa MalloryDivision of Overdose Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Tim K MackeySan Diego Supercomputer Center, University of California, San Diego, CA, USA.ORCID https://orcid.org/0000-0002-2191-7833

Funding

Intramural CDC HHS CC999999United States (US) Centers for Disease Control and Prevention (CDC) NU38PT000294-01-00
6 · The paper itself

Abstract

BACKGROUND AND

aimsCannabis-derived products (CDPs), including cannabidiol (CBD) and tetrahydrocannabinol (THC) products, are widely diverse and readily available through physical and online retail channels in the United States (US) marketplace and may also include claims of treating or providing benefit for health issues. This study aimed to systematically classify the various types of health benefit claim(s) present on CDP listings based on publicly available online marketplace data.

designExploratory analysis to identify health benefit claims. SETTING AND CASES: A total of 624 805 unique CDPs sold in the US on Leafly and Weedmaps, cannabis online marketplace service platforms. MEASUREMENTS: This exploratory study was conducted in four phases: (1) data mining of cannabis e-commerce websites Weedmaps and Leafly for product listings in the US; (2) data filtering, text matching and content coding to identify types of advertised health benefit(s) made; (3) analysis on consumer-generated product reviews for sentiment toward advertised health benefit(s); and (4) ANOVA was used to test differences in mean number of health benefit claims based on product characteristic of route-of-administration (RoA).

findingsA total of 624 805 unique US CDP sales listings from Leafly (n = 50 951) and Weedmaps (n = 573 854) were analyzed. CDP listings with a specific health benefit claim(s) were detected in 998 (1.9%) Leafly and 25 671 (4.47%) Weedmaps CDP listings. The top 5 advertised health benefits were treatment of mood disorders, general discomfort, general wellness, sleep disorders and chronic conditions. Among consumer reviews, 295 (4.6% of consumer reviews from products that advertised health benefit(s)) expressed sentiment toward CDP addressing their health issue with 82.4% being positive, 14.6% negative and 3.1% neutral. We also observed statistically significant differences between RoA and frequency of health benefit claims among those with at least one health benefit claim, with multisystem products (>1RoA) generally having a higher number of average health benefit claims compared with other RoAs.

conclusionsOver 26 000 cannabis-derived products listed on two popular US cannabis online marketplaces have at least one health benefit claim.

Indexed as

CannabisCommerceInternetMedical MarijuanaCannabidiolData MiningDronabinolHumansUnited StatesCannabidiolDronabinolMedical Marijuanacannabiscannabis derived productscannabis industrycannabis marketinge‐commercemarijuana

Identifiers

PMID40867092
PMCPMC13482972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.