ReviewCell & bioscience2025
Biological functions and clinical implications of the CMPK2 across multisystemic diseases.
Review in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Experimental Primary Brain Calcification Model and Its Application to Pathogenesis Mechanism Analysis and Therapeutic Research.Neurology international · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytidine/Uridine monophosphate kinase 2 (CMPK2) is a crucial enzyme responsible for the phosphorylation of nucleotides, specifically converting cytidine monophosphate (CMP) and uridine monophosphate (UMP) into their respective diphosphates, known as cytidine diphosphate (CDP) and uridine diphosphate (UDP). Recent studies have demonstrated that CMPK2 plays a pivotal role in multiple pathophysiological processes, such as cellular nucleotide metabolism, energy homeostasis, and inflammatory response. Dysregulation of CMPK2 has been implicated in a variety of pathologies, including viral infections, neurodegenerative diseases, and autoimmune disorders. Despite its biological significance and interventive potential, knowledge gaps remain with respect to CMPK2, in particular, the precise molecular mechanism and mechanical basis through which it contributes to the onset and progression of underlying diseases. In this regard, this narrative review aims to provide an overview concerning the biological functions of CMPK2, shed light on its involvement in disease pathogenesis alongside clinical relevance, and ultimately highlight potential therapeutic strategies to target CMPK2 across multisystemic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.