Evidence map›Paper›PMID 40866912›Full record

ArticleJournal of experimental & clinical cancer research : CR2025

A novel SOX6 + melanoma cell subtype promotes early microsatellite invasion in Asian acral melanoma through fatty acid transport disorder.

Chuan Lv, Kexin Chen, Tengjiao Wang, Junfeng Jiang, Guanghui Hu, Jianan Gu, Tao Liu, Sheng Wang, Haiying Dai, Yue Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chuan Lv *Department of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China.
Kexin Chen *Department of Plastic Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Tengjiao Wang *Department of Bioinformatics, Center for Translational Medicine, Naval Medical University, Shanghai, 200433, China.
Junfeng JiangDepartment of Histology and Embryology, College of Basic Medicine, Naval Medical University, Shanghai, 200433, China.
Guanghui HuDepartment of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China.
Jianan GuDepartment of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China.
Tao LiuDepartment of Plastic Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Sheng WangDepartment of Bioinformatics, Center for Translational Medicine, Naval Medical University, Shanghai, 200433, China. shengwang@smmu.edu.cn.
Haiying DaiDepartment of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China. dhy230211@163.com.
Yue WangDepartment of Histology and Embryology, College of Basic Medicine, Naval Medical University, Shanghai, 200433, China. wangyuesmmu@163.com.

Funding

Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai, the grants from National Natural Science Foundation of China No. 82273317Shanghai Fourth People's Hospital Research Initiation Grant sykyqd11001Shanghai Science and Technology Commission 21ZR1479100.the Shanghai Key Laboratory of Cell Engineering 14DZ2272300
6 · The paper itself

Abstract

Acral melanoma (AM) is the predominant subtype of melanoma in Asians. Early detection and prevention can significantly improve patient outcomes; however, there is a lack of effective early biomarkers for predicting AM metastasis. Here, we employed single-cell and spatial transcriptomics analyses to investigate early microsatellite lesions of AM and identify biomarkers of invasiveness in these lesions. Our results characterize a highly immunosuppressive microenvironment and metabolic process shifts in early AM microsatellite lesions that promote the metastatic potential. The transcription factor SOX6 is overexpressed in microsatellite lesions and marks a population of highly invasive melanoma cells. The pro-invasive role of overexpressed SOX6 was validated in vivo and in vitro, including its ability to enhance tumor invasion by upregulating cellular glycolysis, disrupt fatty acid transport, and increase intracellular phosphatidylcholine content. This study suggests that SOX6-overexpressing melanoma cells are the main driver subpopulation promoting early invasion of AM and establishes SOX6 and fatty acid transport processes as biomarkers and potential therapeutic targets for early melanoma metastasis.

Indexed as

Fatty AcidsMelanomaSkin NeoplasmsSOXD Transcription FactorsAnimalsBiomarkers, TumorCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceMicrosatellite RepeatsNeoplasm InvasivenessBiomarkers, TumorFatty AcidsSOX6 protein, humanSOXD Transcription FactorsAcral melanoma (AM)Early microsatellitesFatty acid transportSOX6Tumor invasion

Identifiers

PMID40866912
PMCPMC12382077

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.