Evidence map›Paper›PMID 40866863›Full record

ArticleBMC genomics2025

Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle.

Quanzhen Chen, Siqian Chen, Yongjie Tang, Qingyao Zhao, Xilai Zhu, Li Zhi, Xiao Feng, Huaming Mao, Kaixing Qu, Ying Yu

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In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Quanzhen ChenKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Siqian ChenKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yongjie TangKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Qingyao ZhaoKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Xilai ZhuCollege of Physics and Optoelectronic Engineering, Beijing University of Technology, Beijing, 100124, China.
Li ZhiCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, 650500, China.
Xiao FengKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Huaming MaoCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, 650500, China.
Kaixing QuAcademy of Science and Technology, Chuxiong Normal University, Chuxiong, 675000, China. kaixqu@cxtc.edu.cn.
Ying YuKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. yuying@cau.edu.cn.

Funding

Beijing Dairy Industry Innovation Team BAIC06Beijing Natural Municipal Science Foundation 6182021Earmarked Fund for Modern Agro-industry Technology Research System CARS-36the National Key R&D Program of China 2021YFD1200903
6 · The paper itself

Abstract

backgroundDisease is a key factor to shorten productive lifespan of dairy cattle. Shifting from classical 'treating existing diseases' to 'preventing diseases before they occur' is a challenge in high-producing dairy cattle. Immunity plays a crucial role in defending against disease. Substantial evidence indicates that the immune function of taurine ancestry cattle and indicine ancestry cattle are distinct. Therefore, this study aims: (1) to identify core immune genes (CIG) and allele-specific expression (ASE) variants by comparing taurine ancestry dairy cattle with indicine ancestry cattle; and (2) to provide candidate markers for future validation and then used in genomic selection for enhanced immunity in taurine ancestry dairy cattle.

resultsHere, transcriptome and genome data generated by us from the livers and spleens of taurine ancestry dairy cattle (Holstein and Xinjiang Brown) and indicine ancestry cattle (Dehong humped and Dengchuan), along with publicly downloaded transcriptome and genome data of immune cells (monocytes, CD4

conclusionsThis study uses high-throughput omics data to provide new insights into the digitalization of immunity, defined as quantifying immune- and disease-related pathway activity through gene expression levels. Our study also provides candidate markers for future functional validation and genomic selection strategies aimed at enhancing immunity in Holstein cattle.

Indexed as

GenomeTaurineTranscriptomeAllelesAnimalsCattleGene Expression ProfilingGenetic VariationPolymorphism, Single NucleotideQuantitative Trait LociTaurineASEBos taurus indicusBos taurus TaurusCore immune genesImmune score

Identifiers

PMID40866863
PMCPMC12382067

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LicenceCC BY-NC-ND
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