Trial reportBMC anesthesiology2025
Effect of epidural dexmedetomidine on post-operative nausea & vomiting in adult patients undergoing abdominopelvic surgery: a randomized controlled study.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe incidence of postoperative nausea and vomiting (PONV) has been reported to reach as high as 33.5% in patients undergoing abdominal surgeries. Intravenous dexmedetomidine has been shown to be effective in reducing the incidence of PONV, possibly through the inhibition of catecholamine release and decreased opioid requirements. This study aims to investigate the potential efficacy of epidural dexmedetomidine in preventing PONV in patients undergoing abdominal and pelvic surgery under combined general-epidural anesthesia.
methodsThe study enrolled patients aged 18-65 years with an ASA physical status I-III who were scheduled for elective open abdominal or pelvic surgery. Patients were randomized to receive either a single bolus dose of dexmedetomidine during peritoneal closure or placebo. No additional PONV prophylaxis was provided. Patients in the dexmedetomidine group received 2 mg of morphine combined with dexmedetomidine 1 mcg kg
resultsOf the 108 patients randomized between August 2024 to April 2025, 99 were included in the final analysis. The incidence of PONV within 1 and 6 h postoperatively was significantly lower in the dexmedetomidine group compared to placebo (3.8% vs. 30.4%; RR 0.12, 95% CI 0.03-0.52, p < 0.001 and 13.2% vs. 32.6%, RR 0.41, 95% CI 0.18-0.91, p = 0.021), respectively. The severity of postoperative nausea was not different between the groups (p = 0.557). The incidence of postoperative shivering was significantly lower in the dexmedetomidine group (0% vs. 15.2%, p = 0.003).
conclusionsA single administration of epidural dexmedetomidine at 1 mcg kg CLINICAL
trial registrationRetrospectively registered with Thai Clinical Trials Registry (TCTR20250331001) on 31 March 2025.
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