ReviewEmerging infectious diseases2025
Chagas Disease, an Endemic Disease in the United States.
Review in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy and safety of benznidazole in adults with seropositive indeterminate form, Trypanosoma cruzi infection: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Trial
- Treatment with low-dose bicistronic immunotherapy mitigates parasite persistence and improves serological and cardiac outcomes in adult mice infected withEmerging microbes & infections · 2026Article
- Hijacking Host Communication: The Central Role of Extracellular Vesicles in Infectious Disease Pathogenesis.Cells · 2026Review
- Policy Recommendations for Chagas Disease: An Emerging Concern of Public Health Significance for the U.S. Military.The American journal of tropical medicine and hygiene · 2026Article
- Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery.PLoS neglected tropical diseases · 2026Article
- Trypanocidal Activity of Crude Extracts fromJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Chagas Cardiomyopathy in the United States: Testing and Diagnosis Across Real-World Datasets.The American journal of cardiology · 2026Article
- Genetic variability withinResearch square · 2026Article
- Article
- Chagas disease in Florida: An emerging one health challenge in the United States.One health (Amsterdam, Netherlands) · 2026Article
- Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes.PLoS pathogens · 2026Article
- Barriers to Chagas Disease Screening among Primary Care Providers in the United States.The American journal of tropical medicine and hygiene · 2026Article
- Evidence Lacking for Endemic Chagas Disease in the United States.Emerging infectious diseases · 2026Article
- RIG-I-Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction.JACC. Basic to translational science · 2026Article
- Towards new care strategies in a suburban healthcare center in La Matanza, Argentina: performance evaluation of rapid diagnostic tests for Chagas disease in a non-endemic area.Frontiers in cellular and infection microbiology · 2026Article
- Ecological origin and naturalCurrent research in parasitology & vector-borne diseases · 2026Article
- Priced Out of Treatment: The Exorbitant Cost of Antiparasitic Drugs in the United States.Open forum infectious diseases · 2026Article
- Oral Route Infection byPathogens (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chagas disease, caused by Trypanosoma cruzi parasites, is considered endemic to 21 countries in the Americas, excluding the United States. However, increasing evidence of T. cruzi parasites in the United States in triatomine insects, domestic animals, wildlife, and humans challenges that nonendemic label. Several triatomine species are common in the southern United States, where they transmit T. cruzi and invade human dwellings. Wildlife, captive animals, and companion animals, especially dogs, are commonly infected with T. cruzi parasites in this region and serve as reservoirs. Autochthonous human cases have been reported in 8 states, most notably in Texas. Labeling the United States as non-Chagas disease-endemic perpetuates low awareness and underreporting. Classification of Chagas disease as endemic, in particular as hypoendemic, to the United States could improve surveillance, research, and public health responses. Acknowledging the endemicity of Chagas disease in the United States is crucial for achieving global health goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.