Evidence map›Paper›PMID 40866776›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

Quality of life of primary caregivers by severity and control of children's asthma: a systematic review and meta-analysis.

Florian Tomini, Mathura Nagarajah, Sharumilan Ravindran, Borislava Mihaylova

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Florian TominiHealth Economics and Policy Research Unit, Centre for Evaluation and Methods, Wolfson Institute of Population Health, Queen Mary University of London, London, E1 4NS, UK. f.tomini@qmul.ac.uk.ORCID http://orcid.org/0000-0003-2220-5210
Mathura NagarajahBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sharumilan RavindranBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Borislava MihaylovaHealth Economics and Policy Research Unit, Centre for Evaluation and Methods, Wolfson Institute of Population Health, Queen Mary University of London, London, E1 4NS, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review and meta-analysis examined how the quality of life (QOL) of primary caregivers of children with asthma varies according to asthma severity and control. We also compared caregiver QOL with that of caregivers of healthy children and explored variation across specific QOL domains. A comprehensive search was conducted in PubMed, Embase, Scopus, and Web of Science from inception to October 2023. Eligible studies reported caregiver QOL in relation to asthma severity, asthma control, or healthy controls. Study quality was assessed using the Newcastle-Ottawa Scale. QOL scores were standardised to a 0-100 scale (0 = lowest, 100 = highest) and synthesised using random-effects meta-analysis. Thirteen studies were included. Caregivers of healthy children had the highest QOL (79.63; 95% CI: 69.51-89.75), while those of children with severe persistent asthma reported lower scores (59.63; 95% CI: 55.26-64.00). QOL was also higher among caregivers of children with good asthma control (76.71; 95% CI: 67.58-85.84) compared to those with poor control (62.48; 95% CI: 50.15-74.81). Emotional well-being and activity limitations were the domains most consistently associated with severity and control levels. Caregiver QOL is associated with asthma severity and control. Our findings underscore the need for consistent symptom monitoring and management, and suggest that caregiver support should be a routine consideration in paediatric asthma care.

Indexed as

AsthmaCaregiversQuality of LifeChildFemaleHumansMaleSeverity of Illness IndexAsthmaAsthma controlAsthma severityCaregiversPaediatricQuality of lifeSystematic review

Identifiers

PMID40866776
PMCPMC12689705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.