Evidence map›Paper›PMID 40866765›Full record

ArticleClinical rheumatology2025

Comparative analysis of clinical features in diffuse and focal enlargement of IgG4-related autoimmune pancreatitis: a single-center retrospective study.

Dong-Ge Han, Chun-Lin Ying, Lu-Gao Tian, Wei Liu, Zheng He

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dong-Ge HanThe First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Chun-Lin YingThe First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Lu-Gao TianThe First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Wei LiuThe First College of Clinical Medical Science, China Three Gorges University, Yichang, China. liuwei@ctgu.edu.cn.ORCID http://orcid.org/0000-0001-7118-815X
Zheng HeThe First College of Clinical Medical Science, China Three Gorges University, Yichang, China. hezheng7811@qq.com.

Funding

Yichang Medical and Health Research Project A24-2-008
6 · The paper itself

Abstract

backgroundIgG4-related autoimmune pancreatitis (IgG4-AIP) is a rare inflammatory pancreatic disorder mediated by autoimmune mechanisms, primarily characterized by two forms of presentation: diffuse enlargement and focal enlargement. This study aims to analyze the clinical characteristics of diffuse and focal enlargement in IgG4-AIP, thereby enhancing clinicians' understanding of the differences between these two patient groups and ultimately improving patient outcomes.

methodsThis study conducted a retrospective analysis of the clinical data from 40 patients with IgG4-AIP admitted to Yichang Central People's Hospital between January 2019 and December 2024.

resultsAmong the 40 patients with IgG4-AIP, 23 (57.50%) presented with diffuse pancreatic enlargement, while 17 (42.50%) exhibited focal pancreatic enlargement. In the diffuse enlargement group, the most common clinical symptom was abdominal pain (13/23 patients, 56.52%), whereas the focal enlargement group predominantly presented with jaundice (11/17 patients, 64.71%). Additionally, patients in the focal enlargement group were more likely to be misdiagnosed as pancreatic tumors (47.06% vs. 13.04%, P < 0.05). In the focal enlargement group, serum levels of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were significantly elevated compared to the diffuse enlargement group, while serum albumin (ALB) levels were markedly reduced (P < 0.05). The incidence of pancreatic dilatation was significantly higher in the focal enlargement group compared to the diffuse enlargement group (47.06% vs. 13.04%, P < 0.05).

conclusionsThe clinical features of focal enlargement in IgG4-AIP are notably more complex. Clinicians should conduct a thorough analysis of the two presentation forms to develop personalized treatment strategies, thereby improving the prognosis for patients with different manifestations of IgG4-AIP.

Indexed as

Autoimmune DiseasesAutoimmune PancreatitisImmunoglobulin GImmunoglobulin G4-Related DiseaseAbdominal PainAdultAgedAlkaline PhosphataseFemalegamma-GlutamyltransferaseHumansMaleMiddle AgedPancreasPancreatic NeoplasmsRetrospective StudiesAlkaline Phosphatasegamma-GlutamyltransferaseImmunoglobulin GDiffuse enlargementFocal enlargementIgG4-related autoimmune pancreatitis

Identifiers

PMID40866765

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