Evidence map›Paper›PMID 40866713›Full record

ArticleNature2025

Cocaine chemogenetics blunts drug-seeking by synthetic physiology.

Juan L Gomez, Christopher J Magnus, Jordi Bonaventura, Oscar Solis, Fallon P Curry, Marjorie R Levinstein, Reece C Budinich, Meghan L Carlton, Emilya N Ventriglia, Sherry Lam and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Juan L Gomez *Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Christopher J Magnus *Howard Hughes Medical Institute; Janelia Research Campus, Ashburn, VA, USA.ORCID 0000-0001-5640-0116
Jordi BonaventuraBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.ORCID 0000-0002-4745-0151
Oscar SolisBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.ORCID 0000-0002-8285-5891
Fallon P CurryBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Marjorie R LevinsteinBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.ORCID 0000-0003-4360-1503
Reece C BudinichBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Meghan L CarltonBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Emilya N VentrigliaBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Sherry LamBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Le WangDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Ingrid SchoenbornBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
William DunneBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.ORCID 0009-0007-1334-6069
Michael MichaelidesBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA. mike.michaelides@nih.gov.ORCID 0000-0003-0398-4917
Scott M SternsonHoward Hughes Medical Institute; Janelia Research Campus, Ashburn, VA, USA. ssternson@ucsd.edu.ORCID 0000-0002-0835-444X

Funding

Biobehavioral Imaging and Molecular Neuropsychopharmacology of Substance Abuse MechanismsZIADA000069 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI MICHAELIDES, MICHAEL · 2016 to 2025
$18.9M
NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
Intramural NIH HHS ZIA DA000069NIDA NIH HHS T32 DA007234
6 · The paper itself

Abstract

Chemical feedback is ubiquitous in physiology but is challenging to study without perturbing basal functions. One example is addictive drugs, which elicit a positive-feedback cycle of drug-seeking and ingestion by acting on the brain to increase dopamine signalling

Indexed as

CocaineCocaine-Related DisordersDrug-Seeking BehaviorSynthetic BiologyAnimalsChemogeneticsDopamineHabenulaHumansIon Channel GatingIon ChannelsMaleMotivationNucleus AccumbensRatsRats, Sprague-DawleyCocaineDopamineIon Channels

Identifiers

PMID40866713
PMCPMC12527922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.