Evidence map›Paper›PMID 40866708›Full record

ArticleNature2025

The evolution of hominin bipedalism in two steps.

Gayani Senevirathne, Serena C Fernandopulle, Daniel Richard, Stephanie L Baumgart, Anika Liv Christensen, Matteo Fabbri, Jakob Höppner, Harald Jüppner, Peishu Li, Vivien Bothe and 9 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Modular genetic architecture underlies human hand and foot evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. The bacteria of a fig community.Microbiology spectrum · 2026
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Gayani SenevirathneDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-6704-9691
Serena C FernandopulleDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Daniel RichardDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Stephanie L BaumgartDepartment of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA.ORCID 0000-0001-9534-7389
Anika Liv ChristensenDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0009-0009-4345-5885
Matteo FabbriCenter of Functional Anatomy and Evolution, John Hopkins University School of Medicine, Baltimore, MD, USA.
Jakob HöppnerEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9908-2066
Harald JüppnerEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Peishu LiDepartment of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA.ORCID 0000-0002-8299-9166
Vivien BotheMuseum für Naturkunde, Berlin, Germany.
Nadia FröbischMuseum für Naturkunde, Berlin, Germany.
Ian SimcockRadiology Department, Great Ormond Street Hospital, London, UK.
Owen J ArthursRadiology Department, Great Ormond Street Hospital, London, UK.
Alistair CalderRadiology Department, Great Ormond Street Hospital, London, UK.
Naomi FreilichDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Niamh C NowlanSchool of Mechanical and Materials Engineering and University College Dublin (UCD) Conway Institute, Dublin, Ireland.ORCID 0000-0002-9083-6279
Ian A GlassDepartment of Pediatrics, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6762-8407
April CraftDepartment of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Terence D CapelliniDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. tcapellini@fas.harvard.edu.ORCID 0000-0003-3842-8478

Funding

LABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9M
PTH Inverse Agonists as Therapy for Jansens DiseaseR01DK113039 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI THOMAS J GARDELLA, HARALD W. JUEPPNER · 2018 to 2026
$3.5M
Molecular architecture of the human knee joint and pelvis at single cell resolutionR01AR081274 · NIAMS · HARVARD UNIVERSITY · PI Terence D Capellini, April Marie Craft · 2023 to 2026
$3.1M
NIAMS NIH HHS R01 AR081274NICHD NIH HHS R24 HD000836NIDDK NIH HHS R01 DK113039
6 · The paper itself

Abstract

Bipedalism is a human-defining trait

Indexed as

Biological EvolutionHominidaeWalkingAnimalsCartilageChondrocytesFemaleHumansIliumMaleMiceOsteoblastsOsteogenesisPelvis

Identifiers

PMID40866708
PMCPMC12460174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.