Evidence map›Paper›PMID 40866700›Full record

ArticleNature2025

Crystal structures of agonist-bound human cannabinoid receptor CB

Tian Hua, Kiran Vemuri, Spyros P Nikas, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho, Gye Won Han and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Rational Design of GNeuroscience bulletin · 2026
    Article
  2. Dissociable control of depression and visceral pain by the pICNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Library Docking for Cannabinoid-2 Receptor Ligands.Journal of medicinal chemistry · 2026
    Article
  5. Article
  6. Article
  7. Library docking for Cannabinoid-2 Receptor ligands.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tian HuaiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-6132-2068
Kiran Vemuri *Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Spyros P Nikas *Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.ORCID 0000-0001-5052-5292
Yiran WuiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0001-6790-7473
Lu QuiHuman Institute, ShanghaiTech University, Shanghai, China.
Mengchen PuiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0001-6282-2454
Anisha KordeCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Shan JiangCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Jo-Hao HoDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Gye Won HanBridge Institute, University of Southern California, Los Angeles, CA, USA.
Kang DingiHuman Institute, ShanghaiTech University, Shanghai, China.
Xuanxuan LiComplex Systems Division, Beijing Computational Science Research Center, Beijing, China.
Haiguang LiuComplex Systems Division, Beijing Computational Science Research Center, Beijing, China.
Michael A HansonGPCR Consortium, San Marcos, CA, USA.
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.ORCID 0000-0001-5609-434X
Laura M BohnDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. Laura.bohn@ufl.edu.ORCID 0000-0002-6474-8179
Alexandros MakriyannisCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA. a.makriyannis@neu.edu.ORCID 0000-0003-3272-3687
Raymond C StevensiHuman Institute, ShanghaiTech University, Shanghai, China.
Zhi-Jie LiuiHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.ORCID 0000-0001-7279-2893

Funding

Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0M
Cannabinergic Medications for Methamphetamine AddictionR37DA023142 · NIDA · NORTHEASTERN UNIVERSITY · PI MAKRIYANNIS, ALEXANDROS · 2007 to 2016
$7.1M
Structure Function of CB1 Cannabinoid ReceptorR01DA041435 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KATRITCH, VSEVOLOD, MAKRIYANNIS, ALEXANDROS · 2016 to 2020
$3.6M
NIDA NIH HHS P01 DA009158NIDA NIH HHS R01 DA041435NIDA NIH HHS R37 DA023142
6 · The paper itself

Abstract

Cannabinoid receptor 1 (CB

Indexed as

Cannabinoid Receptor AgonistsDronabinolReceptor, Cannabinoid, CB1Binding SitesCannabinolCrystallography, X-RayHumansLigandsModels, MolecularProtein BindingCannabinoid Receptor AgonistsCannabinolDronabinolLigandsReceptor, Cannabinoid, CB1

Identifiers

PMID40866700
PMCPMC12935026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.