Evidence map›Paper›PMID 40866647›Full record

ArticleBulletin of experimental biology and medicine2025

Characteristics of Sarcomere Proteins in Myocardial Sleeves of the Superior Vena Cava and Pulmonary Veins of the Porcine Heart.

A M Kochurova, E A Beldiia, Yu Ya Antonets, G V Kopylova, D V Shchepkin

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A M KochurovaInstitute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.
E A BeldiiaInstitute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia. zgupkabeldya@gmail.com.
Yu Ya AntonetsInstitute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.
G V KopylovaInstitute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.
D V ShchepkinInstitute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial sleeves around caval and pulmonary veins have ectopic activity, which is the main cause of atrial arrhythmias. The morphological and electrophysiological properties of this myocardium differ from those of the atria, but its mechanical activity in large animals has not been studied. We compared the phosphorylation of sarcomere proteins and the functional characteristics of myosin from the left and right atria, superior vena cava, and pulmonary veins of the porcine heart. Myosin from myocardial sleeves contains more of the β-isoform of the heavy chain, i.e., is characterized by slower kinetics of cross-bridge attachment/detachment than atrial myosin. In myocardial sleeves, phosphorylation of troponin T and I, and tropomyosin was lower than in the atria. The phosphorylation features of thin filament proteins may affect the mechanical characteristics of cardiomyocyte contraction, as well as the mechanisms, regulating myocardial contraction, such as the length-dependent regulation and the mechanoelectrical feedback.

Indexed as

MyocardiumPulmonary VeinsSarcomeresVena Cava, SuperiorAnimalsHeart AtriaMyocardial ContractionMyocytes, CardiacMyosin Heavy ChainsPhosphorylationSwineTropomyosinTroponin ITroponin TMyosin Heavy ChainsTropomyosinTroponin ITroponin Tactin-myosin interactioncardiac myosin isoformsin vitro motility assaymyocardial sleevesphosphorylation of sarcomeric proteins

Identifiers

PMID40866647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.