Evidence map›Paper›PMID 40866626›Full record

ArticleNature cardiovascular research2025

Human ocular fluid outflow on-chip reveals trabecular meshwork-mediated Schlemm's canal endothelial dysfunction in steroid-induced glaucoma.

Renhao Lu, Anna M Kolarzyk, W Daniel Stamer, Esak Lee

Erratum issuedAbstract read
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Glaucoma discovery on a chip.Nature cardiovascular research · 2025
    Article
  10. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Renhao LuNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Anna M KolarzykDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
W Daniel StamerDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Esak LeeNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. el767@cornell.edu.ORCID http://orcid.org/0000-0002-5328-6677

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
eNOS-Dependent Mechanoregulation of Intraocular PressureR01EY022359 · NEI · DUKE UNIVERSITY · PI STAMER, W DANIEL · 2012 to 2025
$5.6M
Regulation of Lymphatic Endothelial Cell Junction and DrainageR01HL165135 · NHLBI · CORNELL UNIVERSITY · PI Esak Lee · 2022 to 2026
$2.5M
Tissue-Engineered Models of Lymphatic Drainage in Breast CancerR01CA279560 · NCI · CORNELL UNIVERSITY · PI Esak Lee · 2023 to 2026
$1.6M
BrightFocus Foundation (BrightFocus) NANCI NIH HHS R01 CA279560NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY022359NHLBI NIH HHS R01 HL165135U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA279560U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) EY005722U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) EY022359U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL165135
6 · The paper itself

Abstract

Glaucoma is a leading cause of blindness, featuring elevated intraocular pressure and consequential optic nerve damage

Indexed as

Aqueous HumorEndothelial CellsEndothelium, LymphaticGlaucomaIntraocular PressureLab-On-A-Chip DevicesTrabecular MeshworkAnimalsCells, CulturedExtracellular FluidHumansSchlemm's CanalSignal TransductionVascular Endothelial Growth Factor CVascular Endothelial Growth Factor C

Identifiers

PMID40866626
PMCPMC12443618

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.