ArticleScientific reports2025
Optimization of copper bioremoval from hypersaline environments by the halophilic archaeon Halalkalicoccus sp. Dap5 via response surface methodology.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immobilization of Heavy Metals by Microbial Extracellular Polymeric Substances: Key Mechanisms, Driving Factors, and Research Advances.Applied biochemistry and biotechnology · 2026Review
- Eco-technological potential of salinity-driven functional specialization in Indian solar salterns revealed by integrated culturomics and whole-metagenome profiling.BMC microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper pollution in hypersaline environments poses a significant challenge due to the inefficiency of conventional bioremediation strategies under high salinity and metal stress. Halophilic archaea represent a promising solution for heavy metal removal in saline environments due to their biocompatibility and cost-effectiveness. Here, we investigated the copper removal potential of a Halalkalicoccus sp. Dap5, a halophilic archaeon isolated from the Urmia Lake in Iran. This strain exhibited copper tolerance (MIC: 80 mg/L Cu²⁺) and tolerance to several other toxic metals, including cadmium (Cd²⁺), cobalt (Co²⁺), lead (Pb²⁺), zinc (Zn²⁺), and arsenite (As³⁺) under 15% (w/v) salinity. A Central Composite Design (CCD) was employed within the Response Surface Methodology (RSM) to optimize three key parameters: pH, initial copper concentration, and inoculum percentage, to maximize copper removal. The resulting model was statistically significant (R² = 0.9972, p < 0.0001) and attained a maximum copper removal efficacy of 90.8% at pH 8.1, 28.8 mg/L Cu²⁺, and 4.8% (v/v) inoculum. Microscopic and spectroscopic analyses revealed that copper removal occurred through both biosorption and bioaccumulation mechanisms, supported by increased extracellular polymeric substance (EPS) production and specific functional group interactions identified via FTIR. The results demonstrate that Halalkalicoccus sp. Dap5 exhibits marked tolerance to copper and efficiently removes copper ions from saline environments, making it a valuable candidate for sustainable bioremediation under extreme conditions. This is the first report on optimization of copper bioremoval in a Halalkalicoccus strain using RSM, underscoring its biotechnological significance for green environmental management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.