Evidence map›Paper›PMID 40866609›Full record

ArticleNature chemistry2025

Electrostatic atlas of non-covalent interactions built into metal-organic frameworks.

Zhe Ji, Srijit Mukherjee, Jacopo Andreo, Anna Sinelshchikova, Francesca Peccati, Gonzalo Jiménez-Osés, Stefan Wuttke, Steven G Boxer

Abstract read
In one paragraph

Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe Ji *Department of Chemistry, Stanford University, Stanford, CA, USA. jizhe@pku.edu.cn.ORCID http://orcid.org/0000-0002-8532-333X
Srijit Mukherjee *Department of Chemistry, Stanford University, Stanford, CA, USA.
Jacopo AndreoBasque Center for Materials, Applications and Nanostructures (BCMaterials), Leioa, Spain.ORCID http://orcid.org/0000-0002-8153-5802
Anna SinelshchikovaBasque Center for Materials, Applications and Nanostructures (BCMaterials), Leioa, Spain.ORCID http://orcid.org/0000-0003-0008-709X
Francesca PeccatiCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
Gonzalo Jiménez-OsésCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.ORCID http://orcid.org/0000-0003-0105-4337
Stefan WuttkeBasque Center for Materials, Applications and Nanostructures (BCMaterials), Leioa, Spain. swuttke@agh.edu.pl.ORCID http://orcid.org/0000-0002-6344-5782
Steven G BoxerDepartment of Chemistry, Stanford University, Stanford, CA, USA. sboxer@stanford.edu.ORCID http://orcid.org/0000-0001-9167-4286

Funding

Biophysical Studies of Macromolecules and Molecular AssembliesR35GM118044 · NIGMS · STANFORD UNIVERSITY · PI STEVEN G. BOXER · 2016 to 2026
$7.2M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) GM118044Human Frontier Science Program (HFSP) RGP0047/2022National Science Foundation (NSF) ECCS-2026822NIGMS NIH HHS R35 GM118044
6 · The paper itself

Abstract

Non-covalent interactions are central to the organization of matter and molecular recognition processes, yet they are difficult to characterize. Here we devise a platform strategy to systematically build non-covalent interactions with selective chemical groups into precisely designed configurations by using metal-organic frameworks (MOFs) as the molecular scaffold. Using the vibrational Stark effect benchmarked against computer models, we find the electric field provides a unifying metric for quantifying diverse non-covalent interactions in MOFs and solvation environments. We synthesize and analyse spectroscopically a collection of non-covalent interactions using a nitrile probe within the MOF structure, and identify stabilizing fields as strong as -123 MV cm

Identifiers

PMID40866609
PMCPMC12473737

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.