ArticleNature medicine2025
Global distribution of research efforts, disease burden, and impact of US public funding withdrawal.
Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Consideration of sex/gender aspects in cardiovascular clinical trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Pooled it
- Spatial concordance metrics and related risk factors of brain-peripheral barrier axes: unveiling distinct concordance patterns for mental and neurological axes.Molecular psychiatry · 2026Article
- Global Ophthalmology Research Output Relative to Disease Burden and National Income, 2011-2021.Vision (Basel, Switzerland) · 2026Article
- Global research landscape versus disease burden in pneumoconiosis diagnosis: a dual-source bibliometric analysis [1999-2025].Journal of thoracic disease · 2026Article
- Research waste before research begins: the problem of research-priority mismatch in low- and middle-income countries.Journal of global health · 2026Article
- On the Unfairness of the 'Fair-share Principle' for Health Research.Public health ethics · 2026Article
- Current global estimates, risk factors, and knowledge gaps for Hepatitis E virus (HEV): A scoping review.PLoS neglected tropical diseases · 2026Article
- The Health of Nations Fund: Financing global drug development.PLOS global public health · 2026Article
- The success-failure inversion in modern medicine.Frontiers in public health · 2026Article
- Global burden-integrated analysis of osteoarthritis research-to-translation dynamics, 1999-2023.PloS one · 2026Article
- Phytochemicals: Principles and Practice.Biology · 2025Review
- US divestment in global health: disruption, uncertainty and response.BMJ global health · 2025Review
- Global distribution of research efforts, disease burden, and impact of US public funding withdrawal.Nature medicine · 2025Article
- Reproductive health at crossroads: progress and challenges since the International Conference on Population and Development in Cairo.China population and development studies · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evaluating whether research aligns with the global burden of disease is essential for equitable and effective scientific progress and improvement of human health. Without systematic evaluation of this alignment, science cannot respond to shifting health needs. Here we analyzed the distribution between research and disease, linking 8.6 million disease-specific publications to two decades of global disease burden data using a triangulated large language model approach. We find that since 1999, research and disease burden have seemingly become much more aligned; however, this is mainly because of regional declines in communicable disease burden, whereas the noncommunicable disease burden has increased and globalized. Meanwhile, research effort has not changed to match changes in disease burden. Our simulations suggest that without intentional alignment, the research-disease divergence will probably widen by a third over the next two decades, and be substantially accelerated by the reduction of US public funding for international research. Aligning research with health needs will require strategic investments, improved global coordination, open science policies and stronger, more equitable international partnerships to build resilience in a fragile research ecosystem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.