ArticleCommunications chemistry2025
Photostability of organic fluorophore influenced by adjacent amino acid residues.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- DNA Aptamer-Functionalized Fluorescent Silica Nanoparticles: A Robust Strategy for Specific Detection and Bioimaging of HER2-Overexpressing Breast Cancer.International journal of nanomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence microscopy represents a highly effective tool for examining the microscopic world. Modern microscopic techniques provide advanced temporal and spatial resolutions, while placing high demands on the photostability of fluorophores. Although it is well-known that the photostability of fluorophores is sensitive to their environment, the influence of nearby residues on the photostability of organic fluorophores attached to proteins is not yet fully understood. This study focuses on the influence of residues adjacent to the maleimide-derived fluorophore, specifically attached to cysteine residues in proteins. Under our experimental conditions, methionine, tryptophan, phenylalanine, valine, and leucine were all found to reduce the photostability, whereas glutamate was found to enhance the photostability. To put these experimental observations into perspective, we performed molecular dynamics simulations that offer insights into the mechanistic effects of adjacent residues.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.