Evidence map›Paper›PMID 40866567›Full record

ReviewThe Journal of antibiotics2025

The mechanisms of antibiotic resistance and drug resistance transmission of Klebsiella pneumoniae.

Shuai Zheng, Shuang Li, Duo Zhang, Xindan Zhang, Di Zhou, Qinlong Hou, Gen Li, Huiming Han

Abstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Unveiling the antibiotic resistance pattern inWorld journal of experimental medicine · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuai Zheng *Beihua University, The School of Basic Medicine, Jilin, China.
Shuang Li *Affiliated Hospital of Beihua University, Department of Science andEducation, Jilin, China.
Duo ZhangBeihua University, The School of Basic Medicine, Jilin, China.
Xindan ZhangBeihua University, The School of Basic Medicine, Jilin, China.
Di ZhouBeihua University, The School of Basic Medicine, Jilin, China.
Qinlong HouBeihua University, The School of Basic Medicine, Jilin, China.
Gen LiBeihua University, The School of Basic Medicine, Jilin, China.
Huiming HanBeihua University, The School of Basic Medicine, Jilin, China. hanhuiming@beihua.edu.cn.

Funding

Department of Science and Technology of Jilin Province (Jilin Province Science and Technology Department) JJKH20240092KJJilin Department of Health (Department of Health, Jilin Province) 2022JC021
6 · The paper itself

Abstract

Klebsiella pneumoniae is a ubiquitous Gram-negative pathogen in clinical settings, responsible for pulmonary infections, urinary tract infections, septicemia, and other severe diseases.Over recent years, widespread use of aminoglycosides, quinolones, and β-lactams has driven a marked increase in antimicrobial resistance, compromising treatment efficacy. Here, we review the molecular bases of K. pneumoniae drug resistance, focusing on β-lactamase production, efflux-pump overexpression, target-site modifications, and reduced membrane permeability. We also examine the horizontal spread of resistance determinants via plasmids, integrons, and transposons. By integrating these mechanisms with their transmission pathways, this review provides a comprehensive framework to inform rational antibiotic selection, guide infection-control policies, and support the development of novel anti-resistance strategies.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialDrug Resistance, Multiple, BacterialKlebsiella InfectionsKlebsiella pneumoniaebeta-LactamasesHumansPlasmidsAnti-Bacterial Agentsbeta-Lactamases

Identifiers

PMID40866567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.