Evidence map›Paper›PMID 40866557›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2025

Impact of prophylactic antibiotic duration on surgical site infection rate in neonatal surgery: a multicenter retrospective observational study.

Tomohiro Sunouchi, Jun Fujishiro, Koji Oba, Tetsuya Ishimaru, Chikara Ogimi, Hiroshi Kawashima, Akira Nishi, Kenichi Maruyama, Kiyoshi Tanaka, Hajime Takayasu and 5 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tomohiro SunouchiDepartment of Pediatric Surgery, The University of Tokyo Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4776-8880
Jun FujishiroDepartment of Pediatric Surgery, The University of Tokyo Hospital, Tokyo, Japan. FUJISHIROJ-PSU@h.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-9451-8318
Koji ObaDepartment of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tetsuya IshimaruDivision of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan.
Chikara OgimiDivision of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
Hiroshi KawashimaDepartment of Surgery, Saitama Children's Medical Center, Saitama, Japan.
Akira NishiDepartment of Surgery, Gunma Children's Medical Center, Gunma, Japan.
Kenichi MaruyamaDepartment of Neonatology, Gunma Children's Medical Center, Gunma, Japan.
Kiyoshi TanakaDivision of Pediatric Surgery, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Kanagawa, Japan.
Hajime TakayasuDepartment of General-Pediatric Hepato Biliary Pancreatic Surgery, Kitasato University School of Medicine, Kanagawa, Japan.
Yujiro TanakaDepartment of Pediatric Surgery, Saitama Medical University Hospital, Saitama, Japan.
Kazuko ObanaDepartment of Pediatric Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Ryu YonedaDepartment of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
Akio IshiguroPerinatal Maternal and Child Medical Center, The University of Tokyo Hospital, Tokyo, Japan.
Yutaka MatsuyamaDepartment of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the relationship between the incidence of surgical site infections (SSIs) and the duration of perioperative antibiotic prophylaxis (PAP) in neonatal surgery, and to identify risk factors for SSIs in neonates.

methodsEligible patients were neonates who underwent surgical procedures-primarily in the respiratory and gastrointestinal fields-between January 2014 and December 2023 at seven institutions. All data were retrospectively retrieved from electronic patient records. We estimated the risk difference using a modified least-squares regression model.

resultsOf the 983 patients included, 91 (9%) developed SSIs. A total of 735 patients (75%) received PAP for >24 h. There was no significant difference in risk when PAP duration was <24 h compared with ≥24 h. Independent risk factors for SSIs were an operative time exceeding 120 min, past surgical history, and open surgery.

conclusionIn neonatal surgery, a short duration (<24 h) of PAP may not increase the risk of SSI.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisSurgical Wound InfectionFemaleHumansIncidenceInfant, NewbornMaleOperative TimeRetrospective StudiesRisk FactorsTime FactorsAnti-Bacterial Agents

Identifiers

PMID40866557
PMCPMC12479342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.