Evidence map›Paper›PMID 40866457›Full record

ArticleScientific reports2025

The chloroform fraction of Dracontium spruceanum modulates gene expression in gastric cancer stem cells.

Salyoc Tapia-Rojas, José Amiel-Pérez, Alejandro Fukusaki-Yoshizawa, Obert Marín-Sánchez, Ana Mayanga-Herrera

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Salyoc Tapia-RojasCell Culture and Immunology Lab, Universidad Científica del Sur, Antigua Panamericana Sur Km 19, 15067, Lima, Peru. stapiar@cientifica.edu.pe.
José Amiel-PérezCell Culture and Immunology Lab, Universidad Científica del Sur, Antigua Panamericana Sur Km 19, 15067, Lima, Peru.
Alejandro Fukusaki-YoshizawaLaboratorio de Investigación en Química y Bioquímica de Productos Naturales, Universidad Científica del Sur, Antigua Panamericana Sur Km 19, 15067, Lima, Peru.
Obert Marín-SánchezAcademic Department of Medical Microbiology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, 15081, Lima, Peru.
Ana Mayanga-HerreraCell Culture and Immunology Lab, Universidad Científica del Sur, Antigua Panamericana Sur Km 19, 15067, Lima, Peru. amayanga@cientifica.edu.pe.

Funding

Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica 134-2017-PROCIENCIA
6 · The paper itself

Abstract

Gastric cancer is the fourth most common cancer globally and the leading cause of cancer-related deaths in Peru. Current synthetic treatments often fail to distinguish cancerous cells from healthy cells, resulting in severe side effects and drug resistance. This study aimed to evaluate the effects of the chloroform fraction of Dracontium spruceanum bulb (DSBCl) on cancer stem cells (CSCs) from AGS and KATO III gastric cancer cell lines, which represent primary and metastatic cancers. The methanolic extract was prepared and characterized via thin-layer chromatography to isolate the chloroform fraction. CSCs were identified via the CD44 marker and isolated via magnetic assisted cell sorting. The cytotoxic effect of DSBCl was evaluated to determine the IC

Indexed as

ChloroformGene Expression Regulation, NeoplasticNeoplastic Stem CellsPlant ExtractsStomach NeoplasmsCell Line, TumorHumansKruppel-Like Factor 4Multidrug Resistance-Associated Protein 2ChloroformKLF4 protein, humanKruppel-Like Factor 4Multidrug Resistance-Associated Protein 2Plant Extracts

Identifiers

PMID40866457
PMCPMC12391353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.