ArticleNature communications2025
All-flexible chronoepifluidic nanoplasmonic patch for label-free metabolite profiling in sweat.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Microfluidic valves for wearable sweat analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Cancer Drug Delivery with Nanoparticles and Biomolecules: Stimuli-Responsive, Theranostic, and AI-Guided Approaches.Materials (Basel, Switzerland) · 2026Review
- AI-Ready Multimodal Wearable Biosensors Beyond Glucose: Biofluid Sampling, Sensor Fusion, and Clinical Translation.Biosensors · 2026Review
- Smart wearable biosensors: a transformative synergy between diagnosis and treatment of disease.RSC advances · 2026Review
- Applications of Wearable Sweat Biosensors in Sports Activities with Real-World Cases.Bioengineering (Basel, Switzerland) · 2026Review
- Materials-Structure-Hardware-Algorithm Co-Driven Hierarchical Optimization for Flexible Sensors.Nano-micro letters · 2026Review
- A Flexible Wireless Passive Platform for Decoupled Electrolyte and Temperature Sensing Toward Heat‑Stress Assessment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Thickness Thresholds for Generating Plasmonic Surfaces via Solid-State Dewetting of Ultrathin Silver Films on Soft Polymeric Substrates.ACS omega · 2026Article
- Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.Lab on a chip · 2026Review
- Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Wearable sensors allow non-invasive monitoring of sweat metabolites, but their reliance on molecular recognition elements limits both physiological coverage and temporal resolution. Here we report an all-flexible chronoepifluidic surface-enhanced Raman spectroscopy (CEP-SERS) patch for label-free and chronometric profiling of sweat metabolites. The CEP-SERS patch integrates plasmonic nanostructures in epifluidic microchannels for chronological sweat sampling and molecular analysis. An ultrathin fluorocarbon nanofilm modulates surface chain mobility to guide low-temperature solid-state dewetting, forming large-area silver nanoislands on a structured flexible substrate. The wearable patch adheres conformally to skin, collects sequential sweat samples, and supports label-free and multiplexed SERS detection of assorted metabolites. Machine learning-assisted quantification of lactate, uric acid, and tyrosine yields robust metabolic profiles in distinct physical activity states. This wearable optofluidic platform refines molecular sweat sensing and expands the potential for individualized phenotyping in proactive and data-driven healthcare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.