Evidence map›Paper›PMID 40866347›Full record

ArticleNature communications2025

Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification.

Debayan Dey, Jacob M Mattingly, Natalia Zelinskaya, Christine M Dunham, Graeme L Conn

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Debayan Dey *Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0222-6092
Jacob M Mattingly *Department of Chemistry, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-0202-915X
Natalia ZelinskayaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9387-051X
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, GA, USA. cmdunha@emory.edu.ORCID http://orcid.org/0000-0002-8821-688X
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA. gconn@emory.edu.ORCID http://orcid.org/0000-0002-2419-380X

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
RNA modification and antibiotic resistanceR01AI088025 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Christine M Dunham · 2010 to 2026
$7.9M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM135060 · NIGMS · EMORY UNIVERSITY · PI Lawrence H. Boise, ANITA H. CORBETT · 2020 to 2026
$2.8M
NIAID NIH HHS R01 AI088025NIGMS NIH HHS T32 GM135060NIGMS NIH HHS U24 GM129539Simons Foundation SF349247Wellcome Trust
6 · The paper itself

Abstract

Aminoglycosides disrupt the fidelity of bacterial protein synthesis, but their potent antibacterial activity is threatened by multiple resistance mechanisms, including methylation of their ribosomal RNA (rRNA) binding site. However, the impact of one such resistance-conferring methylation on N1 of helix 44 nucleotide A1408 (m

Indexed as

AminoglycosidesAnti-Bacterial AgentsDrug Resistance, BacterialRNA, RibosomalBinding SitesCryoelectron MicroscopyEscherichia coliMethylationMicrobial Sensitivity TestsMolecular Dynamics SimulationNucleic Acid ConformationRibosomesRNA, BacterialAminoglycosidesAnti-Bacterial AgentsRNA, BacterialRNA, Ribosomal

Identifiers

PMID40866347
PMCPMC12391297

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.