Evidence map›Paper›PMID 40866298›Full record

ArticleRNA (New York, N.Y.)2025

A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability.

Asli Ertekin, Sharon T Noronha, Christable Darko, Francesca Massi, Sean P Ryder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Asli Ertekin *Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, USA.
Sharon T Noronha *Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, USA.ORCID 0009-0006-3195-7683
Christable DarkoDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, USA.
Francesca MassiDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, USA francesca.massi@umassmed.edu sean.ryder@umassmed.edu.
Sean P RyderDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, USA francesca.massi@umassmed.edu sean.ryder@umassmed.edu.ORCID 0000-0003-4960-0739

Funding

Structure to phenotype analysis of a conserved RNA binding protein required for reproductionR01GM139316 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MASSI, FRANCESCA, RYDER, SEAN PATRICK · 2020 to 2023
$2.2M
Post-transcriptional regulation of germline mRNAs in C. elegansR01GM145062 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RYDER, SEAN PATRICK · 2022 to 2025
$1.6M
NIGMS NIH HHS R01 GM139316NIGMS NIH HHS R01 GM145062
6 · The paper itself

Abstract

Sexually reproducing organisms make haploid gametes-oocytes and spermatocytes-that combine during fertilization to make an embryo. While both gametes contain similar DNA content, oocytes contain the bulk of the cytoplasm including maternally supplied mRNAs and proteins required prior to zygotic gene activation. RNA-binding proteins are key regulators of these maternal transcripts. In

Indexed as

ArginineCaenorhabditis elegansCaenorhabditis elegans ProteinsEmbryo, NonmammalianRNA-Binding ProteinsAmino Acid MotifsAnimalsFemaleFertilizationMutationOocytesProtein BindingZinc FingersArginineCaenorhabditis elegans ProteinsRNA-Binding ProteinsfertilizationnematodeoocytereproductionRNA-binding proteintandem zinc finger

Identifiers

PMID40866298
PMCPMC12467108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.