Evidence map›Paper›PMID 40866289›Full record

ArticleJournal for immunotherapy of cancer2025

How can we increase the value of clinical trials with immunotherapy?

Michael B Atkins, David F Mcdermott

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael B AtkinsLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA mba41@Georgetown.edu.ORCID http://orcid.org/0000-0003-3901-9924
David F McdermottBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the 40 years since the initial studies with interleukin-2 led to the Society for Immunotherapy of Cancer's creation, immunotherapy has become a crucial pillar of cancer therapy that is extending and improving countless lives worldwide. Checkpoint inhibitor immunotherapy has become a standard of care treatment for over 20 distinct types of cancer, and other immunotherapy approaches such as novel engineered cytokines, T-cell engagers, oncolytic viruses, personalized cancer vaccines and various cellular therapies are in active development and have already or may eventually receive regulatory approval. This commentary examines what we have learned during this remarkable four-decade drug development journey and how we can best leverage that knowledge to efficiently develop, license and apply future immunotherapy approaches.

Indexed as

Clinical Trials as TopicImmunotherapyNeoplasmsHumansImmunotherapy

Identifiers

PMID40866289
PMCPMC12410652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.