Evidence map›Paper›PMID 40866259›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Hypopituitarism Accompanied with Delusion: The Effects of Growth Hormone Replacement Therapy.

Satoshi Yamagata, Keisuke Sato, Mizuki Tasso, Yuki Nakada, Kaori Sato, Hannah M Nakamura, Takefumi Mori, Shojiro Sawada, Kazunori Kageyama

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Satoshi YamagataDivision of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Keisuke SatoDivision of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Mizuki TassoDivision of Diabetes, Metabolism, and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Yuki NakadaDivision of Diabetes, Metabolism, and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Kaori SatoDivision of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Hannah M NakamuraDivision of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Takefumi MoriDivision of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Shojiro SawadaDivision of Diabetes, Metabolism, and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Kazunori KageyamaDivision of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypopituitarism can cause various psychiatric disorders. We herein report the case of a 60-year-old female with hypopituitarism who presented with severe hyponatremia, impaired consciousness, and delusional disorder. Brain imaging revealed a pituitary macrotumor with hemorrhaging, and the laboratory findings suggested panhypopituitarism. Glucocorticoid replacement therapy improved the hyponatremia, but the delusions persisted. Growth hormone replacement therapy successfully normalized the patient's insulin-like growth factor-1 levels and notably led to the disappearance of delusions. This case highlights the critical role of growth hormone replacement therapy in addressing the psychiatric symptoms associated with growth hormone deficiency.

Indexed as

DelusionsHormone Replacement TherapyHuman Growth HormoneHypopituitarismFemaleHumansHyponatremiaInsulin-Like Growth Factor IMiddle AgedHuman Growth HormoneInsulin-Like Growth Factor Igrowth hormone deficiencypanhypopituitarismpituitary apoplexypituitary tumor

Identifiers

PMID40866259
PMCPMC13070593

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.