Successful Management of Infective Endocarditis Utilizing Rapid High-performance Liquid Chromatography-based Therapeutic Drug Monitoring: Balancing Linezolid Efficacy and Thrombocytopenia Risk.

Shunta Kobayashi, Ruriko Numata, Tomoko Machino-Ohtsuka, Hiromichi Suzuki, Tomoko Ishizu

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Periorbital and Central Nervous System Infection Due toMicroorganisms · 2025
Article

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Shunta KobayashiDepartment of Cardiology, Institute of Medicine, University of Tsukuba, Japan.

Ruriko NumataDepartment of Cardiology, Institute of Medicine, University of Tsukuba, Japan.

Tomoko Machino-OhtsukaDepartment of Cardiology, Institute of Medicine, University of Tsukuba, Japan.

Hiromichi SuzukiDepartment of Clinical Laboratory Medicine, Institute of Medicine, University of Tsukuba, Japan.

Tomoko IshizuDepartment of Cardiology, Institute of Medicine, University of Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linezolid (LZD) is an effective alternative to vancomycin (VCM) for the treatment of methicillin-resistant Staphylococcus-associated infective endocarditis (IE), including cases involving prosthetic materials. However, the prolonged use often leads to thrombocytopenia, thus highlighting the importance of therapeutic drug monitoring (TDM) for dose optimization. We herein present the case of slowly progressive methicillin-resistant Staphylococcus epidermidis IE affecting a mitral annuloplasty ring in a 69-year-old afebrile patient whose only manifestation was a recurrent cerebral embolism. TDM-guided LZD dose adjustments using rapid high-performance liquid chromatography enabled the successful completion of a six-week antibiotic course while preventing severe thrombocytopenia and ensuring no further stroke recurrence.

Indexed as

Anti-Bacterial AgentsDrug MonitoringEndocarditis, BacterialLinezolidStaphylococcal InfectionsThrombocytopeniaAgedChromatography, High Pressure LiquidHumansMaleStaphylococcus epidermidisTreatment OutcomeAnti-Bacterial AgentsLinezolidinfective endocarditislinezolidtherapeutic drug monitoringthrombocytopenia

Identifiers

PMID40866257

DOI10.2169/internalmedicine.5890-25

PMCPMC13070577

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