ArticleInternal medicine (Tokyo, Japan)2026
Hepatic Decompensation Caused by IgG4-positive Plasma Cell Infiltration Mimicking Sclerosing Cholangitis, Who Achieved a Four-year Survival by Glucocorticoid Treatment.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A 51-year-old man was referred to our hospital because of a worsening liver function after a follow-up of13 years for elevated hepatobiliary enzyme levels of unknown etiology. The IgG4 (4,990 mg/dL) levels were markedly elevated. Imaging revealed splenomegaly, intrahepatic bile duct dilatation, and an early enhancement area in the right lobe. A liver biopsy of the enhanced area revealed IgG4-positive plasma cell infiltration. Although glucocorticoid therapy was initiated due to a suspicion of IgG4-related sclerosing cholangitis, his liver function deteriorated after experiencing variceal bleeding. Liver transplantation for decompensation was considered, but it was not performed due to pneumocystis pneumonia. During gradual tapering of glucocorticoids, the pneumocystis pneumonia improved and his liver function stabilized.
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