Evidence map›Paper›PMID 40866084›Full record

ReviewBMJ open quality2025

Fatal anaphylactic shock following cefoperazone-sulbactam re-exposure: a short report on systemic gaps in adverse drug reaction management.

Xiaomei Mo, Guanhua Liang, Wenhui Gan, Lili Xu, Meixing Yan

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMJ open quality, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaomei MoWomen and Children's Hospital, Qingdao University, Qingdao, China.ORCID 0000-0002-7717-7432
Guanhua LiangShandong Second Medical University, Weifang, China.ORCID 0009-0008-2768-4218
Wenhui GanOcean University of China, Qingdao, China.ORCID 0009-0000-5053-0390
Lili XuShandong Adverse Drug Reaction Monitoring Center, Shandong, China meixing@163.com 63550433@qq.com.ORCID 0009-0007-0396-164X
Meixing YanWomen and Children's Hospital, Qingdao University, Qingdao, China meixing@163.com 63550433@qq.com.ORCID 0000-0001-9361-2492

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report presents a case of fatal anaphylactic shock following re-exposure to cefoperazone-sulbactam, highlighting systemic gaps in adverse drug reaction (ADR) management. The patient initially tolerated the drug without immediate adverse effects but developed severe hypersensitivity reactions upon subsequent exposures, ultimately leading to death. Analysis revealed that the healthcare team underestimated the risk of delayed IgE-mediated sensitization, and critical allergy information was not documented in the emergency department (ED). Additionally, the electronic health record (EHR) system lacked real-time allergy alerts. Fragmented communication during care transitions and technological deficiencies further exacerbated the risks.

Indexed as

AnaphylaxisCefoperazoneDrug-Related Side Effects and Adverse ReactionsSulbactamAnti-Bacterial AgentsFatal OutcomeFemaleHumansAnti-Bacterial AgentsCefoperazoneSulbactamAntibiotic managementMedication safetyPatient safety

Identifiers

PMID40866084
PMCPMC12410647

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.