ArticleBMJ open2025
Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between acute kidney injury and delirium in critically ill patients: a retrospective cohort study using two independent databases.Critical care (London, England) · 2026Article
- Research advances on acute kidney injury and brain dysfunction.Frontiers in nephrology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute kidney injury (AKI) and delirium are common clinical complications of critical illness. Relatively few studies have evaluated the relationship between AKI and delirium. This systematic review will assess this association among critically ill patients. METHODS AND ANALYSIS: We will conduct comprehensive searches of databases, including Ovid MEDLINE, Ovid Embase, CINAHL, Scopus, Web of Science Core Collection and the Cochrane Library, using keywords to capture the existing literature related to AKI and delirium. Searches will range from inception to January 2025. Two reviewers will independently screen, select and extract studies using the web-based tool, Covidence. Inclusion criteria will include clinical trials or observational cohorts reporting both AKI and delirium in patients admitted to intensive care units. Case reports, case series and preclinical or experimental studies will be excluded. The quality and risk of bias will be assessed using the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk-of-Bias tool for randomised controlled trials. The primary outcome will be the proportion of critically ill patients with AKI who develop delirium. Secondary outcomes will include the proportion of patients with delirium stratified by AKI severity or receipt of renal replacement therapy as well as clinical factors associated with delirium, mortality and health service outcomes, including organ support use and lengths of stay. ETHICS AND DISSEMINATION: Ethics approval is not required for this study, as all data included in this evaluation are already published, and our study will not directly involve human participants. Findings will be disseminated through academic conferences and published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD420251001864.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.