ArticleJournal of the American College of Cardiology2025
Prevalence and Predictors of Neurocognitive Dysfunction in Adults With Congenital Heart Disease: Results From MINDS-ACHD.
Article in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
backgroundAdults with congenital heart disease (ACHD) undergo repeated cardiac interventions, develop cardiac complications including atrial fibrillation, heart failure, and stroke, and may have genetic vulnerabilities for neurocognitive deficits (NCDs). However, NCDs have not been well studied in this population.
objectivesThe aim of this study was to examine the prevalence and risk factors associated with NCDs in young adults with moderate and severe complex congenital heart disease (CHD).
methodsThis was a prospective study of objective (cognitive battery of the National Institutes of Health [NIH] Toolbox) and subjective (NeuroQOL Item Bank v2) measures of neurocognitive function in ACHD patients (ages 18-30 years) from 14 North American ACHD centers. Multivariable regression was used to examine predictors of neurocognitive function.
resultsOverall, 467 ACHD participants were enrolled (82 dextro-transposition of the great arteries, 123 tetralogy of Fallot, 132 single ventricle, and 130 other CHD). The mean age was 24.5 years, 44% were male, 81% were White, and 78% had NYHA functional class I. For the total cohort, 34% scored at least 1 standard deviation below the normative mean on the NIH Toolbox Total Composite Score and 22% scored at least 1 standard deviation below the normative mean on the NeuroQOL. Education and NYHA functional class were independently associated with NIH Toolbox scores. Education, body mass index, atrial arrhythmias, depression, and anxiety were independently associated with NeuroQOL scores.
conclusionsNCDs are prevalent in young adults with moderate and severely complex CHD, with approximately one-third having objective NCDs and one-fifth subjective NCDs. These findings emphasize the importance of integrating neurocognitive assessments into routine ACHD care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.