Evidence map›Paper›PMID 40866040›Full record

ArticleJACC. Basic to translational science2025

Evaluation of Tideglusib as a Disease Modifying Therapy in Murine Models of Arrhythmogenic Cardiomyopathy.

Nipun Malhotra, Omer Cavus, Michael J Wallace, John T Bobik, Kevin You, Sarah S Takenaka, Danielle Abdallah, Eleanor J Mohler, Steve Antwi-Boasiako, Nathaniel P Murphy and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nipun MalhotraThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Surgery/Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Omer CavusThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Surgery/Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Michael J WallaceThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
John T BobikThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Surgery/Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Kevin YouThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Sarah S TakenakaThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Surgery/Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Danielle AbdallahThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Eleanor J MohlerThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Steve Antwi-BoasiakoThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Nathaniel P MurphyThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Holly Sucharski-ArgallThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Xianyao XuThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Stephen P ChelkoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA.
Thomas J HundThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Internal Medicine/Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Jason D RobertsPopulation Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Peter J MohlerThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Internal Medicine/Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Mona El RefaeyThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart, and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Surgery/Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address: Mona.elrefaey@osumc.edu.

Funding

Novel Roles of Protein phosphatase 2A in Cardiac ArrhythmiaR01HL175380 · NHLBI · OHIO STATE UNIVERSITY · PI Mona El Refaey · 2024 to 2026
$1.9M
Role of TREK-1 in modulating cardiac excitability and arrhythmiaR01HL156652 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2021 to 2024
$1.7M
Novel role for the spectrin cytoskeleton in regulation of cardiac fibroblast activity, long-range communication and injury-induced fibrosisR01HL171689 · NHLBI · OHIO STATE UNIVERSITY · PI Thomas Jeffrey Hund · 2024 to 2026
$1.6M
Defining new pathways for cardiac automaticityR00HL146969 · NHLBI · OHIO STATE UNIVERSITY · PI EL REFAEY, MONA · 2021 to 2023
$747k
NHLBI NIH HHS R00 HL146969NHLBI NIH HHS R01 HL156652NHLBI NIH HHS R01 HL171689NHLBI NIH HHS R01 HL175380
6 · The paper itself

Abstract

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease, and current pharmacological therapies are directed toward the management of electrical manifestations. To date, none address the underlying pathophysiology of this progressive condition. We evaluated the therapeutic efficacy of Tideglusib (TD) in Ank2 cardio-selective-knockout and homozygous desmoglein-2 mutant ACM mouse models. TD was able to prevent and reverse the reduced cardiac function in treated mice. Moreover, TD-treated adult mice displayed a reduction in ventricular arrhythmia following adrenergic stimulation. We provide compelling preclinical data for TD as a potential therapy for patients with ACM.

Indexed as

ankyrin-Barrhythmiaarrhythmogenic cardiomyopathycardiovascular diseasedesmoglein-2GSK-3βTideglusib

Identifiers

PMID40866040
PMCPMC12399120

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.