Evidence map›Paper›PMID 40865685›Full record

Observational studyJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025

Multi-center investigation of cardiac diffusion tensor imaging in healthy volunteers by the Society of Cardiovascular Magnetic Resonance Cardiac Diffusion Special Interest Group NETwork (SIGNET).

Irvin Teh, Kévin Moulin, Pedro F Ferreira, Julie Absil, Maryam Afzali, Peter Agger, Behnaz Akbari, Anthony H Aletras, Satoru Aono, Charles Benton and 40 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Irvin TehLeeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK. Electronic address: i.teh@leeds.ac.uk.
Kévin MoulinDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Pedro F FerreiraRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust and National Heart and Lung Institute, Imperial College London, London, UK.
Julie AbsilRadiologie, Imagerie par Résonance Magnétique, Hôpital Erasme, Brussels, Belgium.
Maryam AfzaliLeeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.
Peter AggerDepartment of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Behnaz AkbariBoston University School of Medicine, Boston, Massachusetts, USA.
Anthony H AletrasClinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Satoru AonoDepartment of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
Charles BentonNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Suryava BhattacharyaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Pierre CroisilleCREATIS Laboratory, Univ. Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM 1294, Saint-Etienne, France.
Yves De BrueckerDepartment of Radiology, Imelda Hospital Bonheiden, Belgium.
Erica Dall'ArmellinaLeeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK.
Daniel B EnnisDepartment of Radiology, Stanford University, Stanford, California, USA.
Carl GlessgenCardiovascular radiology unit, Radiology clinics, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Anna Glinska2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
Sandra HaltmeierInstitute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
Ariel HannumDepartment of Radiology, Stanford University, Stanford, California, USA.
Erik HedströmClinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Tawfik HusseinWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA.
Sarah JonesCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.
George JoyBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Karen KettlessSiemens Healthcare A/S, Ballerup, Denmark.
Won Yong KimDepartment of Clinical Medicine, Aarhus University, Aarhus N, Denmark; Department of Cardiology, Aarhus University, Aarhus N, Denmark.
Sebastian KozerkeInstitute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
Julie MagatCNRS, CRMSB, UMR 5536, IHU Liryc, University of Bordeaux, Bordeaux, France.
Raja MuthupillaiDepartment of Radiology, University of Houston, Houston, Texas, USA.
Reza NezafatDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Sonia Nielles-VallespinRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust and National Heart and Lung Institute, Imperial College London, London, UK.
John OshinskiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA.
Valéry OzenneCNRS, CRMSB, UMR 5536, IHU Liryc, University of Bordeaux, Bordeaux, France.
Dudley J PennellRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust and National Heart and Lung Institute, Imperial College London, London, UK.
Roderick PettigrewSchool of Engineering Medicine/ENMED, Texas A&M University and Houston Methodist Hospital, Houston, Texas, USA.
Iain PierceBarts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
Betty RamanDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Agnieszka Sabisz2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
Jürgen E SchneiderLeeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK.
Janet H ShermanBoston University School of Medicine, Boston, Massachusetts, USA.
Abhishek ShetyeBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Rolf SymonsDepartment of Radiology, Imelda Hospital Bonheiden, Belgium.
Philippe ThomaRadiologie, Imagerie par Résonance Magnétique, Hôpital Erasme, Brussels, Belgium.
Thomas TreibelBarts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
Satonori TsunetaDepartment of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
Jean-Paul ValleeCardiovascular radiology unit, Radiology clinics, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Niels VejlstrupDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Magalie ViallonCREATIS Laboratory, Univ. Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM 1294, Saint-Etienne, France.
Christopher NguyenCleveland Clinic, Heart Vascular Thoracic Institute, Cardiovascular Innovation Research Center, Cleveland, Ohio, USA.
Andrew D ScottRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust and National Heart and Lung Institute, Imperial College London, London, UK.
Christian T StoeckInstitute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; Center for Preclinical Development, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Funding

Cardiopulmonary Exercise MRI in Heart Failure with Preserved Ejection FractionR01HL158077 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2021 to 2025
$3.7M
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Microstructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2M
Modeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4M
BHF RG/F/23/110115British Heart Foundation UK PG/19/1/34076NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL158077NHLBI NIH HHS R01 HL159010NIBIB NIH HHS R01 EB033853Wellcome Trust 219536/Z/19/Z
6 · The paper itself

Abstract

backgroundCardiac diffusion tensor imaging (cDTI) is an emerging technique for microstructural characterization of the heart and has shown clinical potential in a range of cardiomyopathies. However, there is substantial variation reported for in vivo cDTI results across the literature, and sensitivity of cDTI to differences in imaging sites, scanners, acquisition protocols, and post-processing methods remains incompletely understood.

methodsSIGNET is a prospective multi-center, observational study in traveling and non-traveling healthy volunteers. The study was initiated by the executive board of the Society of Cardiovascular Magnetic Resonance (SCMR) Cardiac Diffusion Special Interest Group (SIG) as a follow-up to a previous multi-center study on phantom validation of cardiac DTI and a recently published SCMR consensus statement on cardiac diffusion MRI. The study has been developed by the Project Management Committee in consultation with the SCMR cardiac diffusion SIG, which includes international experts in cardiac diffusion MRI. To date, more than 20 international institutions have engaged with the study, including sites that are new to cardiac DTI, making this the largest collaborative effort in the field. DISCUSSION: SIGNET will provide important information about the key sources of variation in cardiac DTI. This will help rationalize strategies for addressing and minimizing such variation. Harmonization of protocols in this and future studies will underpin efforts to translate cardiac DTI for clinical application.

Indexed as

Diffusion Tensor ImagingHeartAdultConsensusCooperative BehaviorHealthy VolunteersHumansMalePredictive Value of TestsProspective StudiesReference ValuesReproducibility of ResultsSocieties, MedicalCardiac DTIHeartInter-site variationIntra-site variationMyocardiumPulse sequence development

Identifiers

PMID40865685
PMCPMC12703782

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