ArticleHeart rhythm2026
Habitual sleep duration and QT variability index: Correlates of ventricular repolarization lability and all-cause mortality.
Article in Heart rhythm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- GLP-1 receptor agonist therapy is associated with reduced atrial fibrillation recurrence after catheter ablation: a meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- The interactive effect of long nighttime sleep and daytime napping on QTc prolongation in hypertensive adults.BMC cardiovascular disorders · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundHabitually short and long sleep duration have been associated with adverse cardiovascular outcomes, but their potential effects on ventricular repolarization lability are unknown. The QT variability index (QTVI) is a validated electrocardiographic measure of ventricular repolarization lability that predicts sudden cardiac death and all-cause mortality.
objectiveThis study aimed to characterize associations among habitual sleep duration, QTVI, and all-cause mortality.
methodsData from 1123 adults in the Sleep Heart Health Study without sleep-disordered breathing were analyzed. Self-reported habitual sleep duration was categorized as ≤5, 6, 7, 8 (reference), or ≥9 h/night. QTVI was derived from a single-lead electrocardiogram during in-home polysomnography. Associations between sleep duration and QTVI were examined using robust linear regression. Proportional hazards regression was used to assess the association between QTVI and all-cause mortality.
resultsBoth short (≤5 hours) and long sleep duration (≥9 hours) were associated with higher QTVI than 8 hours of habitual sleep after adjustment for demographic and clinical covariates (ΔQTVI = 0.18; 95% confidence interval [CI] 0.05-0.31; ΔQTVI = 0.15; 95% CI 0.02-0.28, respectively). Higher QTVI predicted greater mortality risk, with the highest quartile associated with more than double the risk (hazard ratio 2.14; 95% CI 1.45-3.17). The QTVI-mortality association varied by sleep duration (P = .04 for interaction), with the strongest effect in those reporting ≤5 hours of sleep (hazard ratio 3.12; 95% CI 1.85-5.26).
conclusionIn adults without sleep-disordered breathing, short and long habitual sleep duration were associated with increased ventricular repolarization lability. Elevated QTVI independently predicted all-cause mortality, particularly in short sleepers, suggesting that sleep duration may influence electrophysiological vulnerability and arrhythmic risk.
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