Evidence map›Paper›PMID 40865440›Full record

ArticleThe International journal on drug policy2025

Pre-implementation findings on the barriers and potential solutions to initiate same-day antiretroviral therapy among people who inject drugs in Malaysia.

David Oliveros, Grazele Jenarun, N A Mohd Salleh, Rumana Saifi, Valerie A Earnshaw, Lynn M Madden, Daniel J Bromberg, Ryan A Sutherland, Benjamin M Nikitin, Adeeba Kamarulzaman and 1 more

Abstract read
In one paragraph

Article in The International journal on drug policy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David OliverosSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States; Center for Interdisciplinary Research on AIDS (CIRA), Yale School of Medicine, Yale University, New Haven, CT, United States. Electronic address: david.oliveros@yale.edu.
Grazele JenarunDepartment of Social and Preventive Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
N A Mohd SallehDepartment of Social and Preventive Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS, Universiti Malaya, Kuala Lumpur, Malaysia.
Rumana SaifiDepartment of Social and Preventive Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS, Universiti Malaya, Kuala Lumpur, Malaysia.
Valerie A EarnshawDepartment of Human Development and Family Sciences, University of Delaware, Newark, DE, United States.
Lynn M MaddenSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States; APT Foundation, New Haven, CT, United States.
Daniel J BrombergSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States; Center for Interdisciplinary Research on AIDS (CIRA), Yale School of Medicine, Yale University, New Haven, CT, United States.
Ryan A SutherlandSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States.
Benjamin M NikitinSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States.
Adeeba KamarulzamanMonash University Malaysia, Kuala Lumpur, Malaysia.
Frederick L AlticeSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States; Center for Interdisciplinary Research on AIDS (CIRA), Yale School of Medicine, Yale University, New Haven, CT, United States; APT Foundation, New Haven, CT, United States.

Funding

Malaysian Implementation Science Training (MIST) Program in HIVD43TW011324 · FIC · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE, Rafdzah Zaki · 2020 to 2026
$1.8M
Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy InterventionR01TW012674 · FIC · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2023 to 2025
$710k
FIC NIH HHS D43 TW011324FIC NIH HHS R01 TW012674
6 · The paper itself

Abstract

backgroundRapid-start antiretroviral therapy (RS-ART), including same-day ART (SD-ART), effectively improves individual and public health by speeding up treatment initiation but is underutilized among people who inject drugs (PWID). As a pre-implementation activity, we assessed barriers and facilitators to SD-ART for PWID in Malaysia using insights from multiple stakeholders.

methodsWe conducted focus groups (n = 4) using nominal group technique (NGT), a mixed-methods research strategy, with PWID, HIV specialists, and community health workers (CHWs) in Greater Kuala Lumpur, Malaysia. This method involved open questions, round-robin listing of ideas, and participant voting to derive a rank-ordered consensus on major implementation barriers and facilitators, organized according to the socioecological model.

resultsAmong PWID (n = 5: 15 votes), the highest-ranking barriers included fear of police (40 %), procedural complexity (30 %), and discomfort with HIV providers (27 %). HIV specialists (n = 12: 36 votes) ranked readiness for treatment (27 %), risk of opportunistic infections (20 %), and incarceration concerns (13 %) as key barriers. CHWs (n = 7: 21 votes) pointed to complex appointment systems (33 %), delays in confirmatory testing (19 %), and stigma-reinforcing interactions with clinicians (19 %) as obstacles. Facilitators for PWID included initiating ART before reviewing results (27 %) and same-day counseling (27 %). For HIV specialists, essential strategies were enhancing NGO partnerships (33 %) and expanding ART options like dolutegravir (20 %). CHWs recommended simplifying treatment processes (33 %) and creating a dedicated clinic for HIV services (29 %).

conclusionDespite available harm reduction and HIV treatment services, structural and interpersonal stigma significantly hinder SD-ART initiation among PWID in Malaysia. Addressing stigma through tailored ART initiation strategies is crucial for closing this implementation gap.

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsSubstance Abuse, IntravenousAdultCommunity Health WorkersFemaleFocus GroupsHealth Services AccessibilityHumansMalaysiaMaleSocial StigmaAnti-HIV AgentsAnti-Retroviral AgentsAntiretroviral therapyHIVPWIDRS-ARTStigma

Identifiers

PMID40865440
PMCPMC12525725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.