Evidence map›Paper›PMID 40865039›Full record

ReviewChemMedChem2025

Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone-Immune Crosstalk.

Rachel Wei Li, Sara Alzaanin, Zongyou Yin, Paul N Smith

Abstract readReview
In one paragraph

Review in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel Wei LiSchool of Medicine and Psycology, Australian National University, College of Science, Australian National University Canberra, Australian Capital Territory, Canberra, ACT 2601, Australia.ORCID https://orcid.org/0000-0001-7053-7928
Sara AlzaaninSchool of Medicine and Psycology, Australian National University, College of Science, Australian National University Canberra, Australian Capital Territory, Canberra, ACT 2601, Australia.ORCID https://orcid.org/0009-0002-3534-5386
Zongyou YinSchool of Medicine and Psycology, Australian National University, College of Science, Australian National University Canberra, Australian Capital Territory, Canberra, ACT 2601, Australia.ORCID https://orcid.org/0000-0002-0800-4490
Paul N SmithSchool of Medicine and Psycology, Australian National University, College of Science, Australian National University Canberra, Australian Capital Territory, Canberra, ACT 2601, Australia.ORCID https://orcid.org/0000-0001-6891-5694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite significant advancesin osteoimmunology, the mechanistic underpinnings of immune-skeletal crosstalk remain insufficiently characterized, particularly at the molecular and submolecular scales. The present article introduces quantum osteoimmunology as a novel field of research exploring how quantum mechanical phenomena, such as coherence, tunneling, entanglement, and wavefunction superposition, may influence osteoimmune signaling dynamics. It argues that the current deterministic, temporally linear models of immune activation may overlook the probabilistic and non-linear nature of molecular events governed by quantum principles. Integrating quantum principles into osteoimmune research could offer new explanatory models for unresolved questions in bone-immune physiology and pathology. In parallel, the unique photophysical characteristics of quantum nanomaterials, such as size-tunable emission spectra, high quantum yields, and photostability, present unprecedented opportunities for high-resolution biomarker detection, enabling real-time, ultrasensitive diagnostics for osteoimmune pathologies. Moreover, these materials exhibit significant potential for the development of traceable, precision-targeted therapeutic delivery systems, as well as for high-resolution in vitro and in vivo bioimaging applications. Ultimately, quantum mechanics holds the potential to revolutionize osteoimmunology-conceptually, by reshaping one's understanding of immune-skeletal interactions at the subatomic level; and practically, by driving innovations in diagnostics, targeted therapeutics, and real-time molecular imaging.

Indexed as

Bone and BonesQuantum TheoryAnimalsHumansbioimagingdiagnosticsosteoimmune signalingquantum dotsquantum mechanicsquantum osteoimmunologytherapeutic delivery

Identifiers

PMID40865039
PMCPMC12503904

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.