Evidence map›Paper›PMID 40864971›Full record

ArticleACS synthetic biology2025

Rewiring Aromatic Compound Consumption: Chromosomal Amplification and Evolution of a Foreign Pathway in

Alyssa C Baugh, Melissa P Tumen-Velasquez, Isabella R Zempel, Chantel V Duscent-Maitland, Lauren E Slarks, Justin B Defalco, Christopher W Johnson, Gregg T Beckham, Ellen L Neidle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alyssa C BaughDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.
Melissa P Tumen-VelasquezDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.
Isabella R ZempelDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.
Chantel V Duscent-MaitlandDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.
Lauren E SlarksDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.
Justin B DefalcoDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.
Christopher W JohnsonRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, Colorado 80401, United States.ORCID 0000-0002-2979-4751
Gregg T BeckhamRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, Colorado 80401, United States.ORCID 0000-0002-3480-212X
Ellen L NeidleDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-1665-5303

Funding

Department of Energy (DOE) DE-AC02-06CH11357Department of Energy (DOE) DE-AC36-08GO28308Department of Energy (DOE) DE-SC0022220National Science Foundation MCB2225858
6 · The paper itself

Abstract

Rational engineering strategies that seek to harness the remarkable diversity of microbial metabolism can be limited by incomplete biological knowledge. As described here, a novel approach to address this challenge involved replacing a native pathway for degrading lignin-derived aromatic compounds via

Indexed as

AcinetobacterChromosomes, BacterialMetabolic EngineeringBacterial ProteinsGene DosageLigninMutationBacterial ProteinsLigninAcinetobacter baylyiaromatic compoundsgene amplificationprotocatechuate

Identifiers

PMID40864971
PMCPMC12455638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.